| Identification | Back Directory | [Name]
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, 3-[2-(3,4-dichlorophenoxy)ethyl] 5-[2-(4-morpholinyl)-1-(4-morpholinylmethyl)ethyl] ester | [CAS]
727358-25-0 | [Synonyms]
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, 3-[2-(3,4-dichlorophenoxy)ethyl] 5-[2-(4-morpholinyl)-1-(4-morpholinylmethyl)ethyl] ester | [Molecular Formula]
C29H39Cl2N3O7 | [MOL File]
727358-25-0.mol | [Molecular Weight]
612.54 |
| Chemical Properties | Back Directory | [Boiling point ]
721.6±60.0 °C(Predicted) | [density ]
1.256±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
6.38±0.10(Predicted) | [color ]
white to beige | [InChIKey]
WZWJKBCMEZITJW-UHFFFAOYSA-N | [SMILES]
CC1C(C(OCCOC2=CC(Cl)=C(C=C2)Cl)=O)=C(NC(C)=C1C(OC(CN3CCOCC3)CN4CCOCC4)=O)C |
| Hazard Information | Back Directory | [Uses]
LAU-0901, a PAF receptor antagonist, possesses highly neuroprotective activity. LAU-0901 inhibits apoptosis[1]. | [Biological Activity]
LAU-0901 is a highly potent and selective platelet-activating factor (PAF) receptor antagonist th at is neuroprotective in experimental strokeand protective in a variety of inflammation models. LAU-0901 blocks pro-inflammatory signaling. LAU-0901 demonstrated efficacy in a mouse model of glioblastoma multiforme (GBM) alone and in combination with Avastin. | [References]
[1] Ludmila Belayev, et al. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp Neurol. 2008 Dec;214(2):253-8. DOI:10.1016/j.expneurol.2008.08.009 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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