| Identification | Back Directory | [Name]
L-NORADRENALINE BITARTRATE | [CAS]
108341-18-0 | [Synonyms]
NORADRENALINE
L-ARTERENOL BITARTRATE
NOREPINEPHRINE BITARTRATE
L-Nradrenaline bitartrate
Noradrenaline tartrate CRS
L-NORADRENALINE BITARTRATE
L-NOREPINEPHRINE BITARTRATE
(-)-ARTERENOL BITARTRATE SALT
NOREPINEPHRINE BITARTRATE USP
L-NORADRENALINE BITARTRATE 98+%
L-Arterenol hydrogen L-tartrate
L-Norepinephrine bitartrate salt
L-Arterenol Bitartrate Monohydrate
L-Norepinephrine bitartrate hydride
Levarterenol bitartrate monohydrate
L-(-)-NOREPINEPHRINE-(+)-BITARTRATE
Levoarterenol Bitartrate Monohydrate
L-NORADRENALINE BITARTRATE USP/EP/BP
Norepinephrine (bitartrate Monohydrate)
(R)-(-)-NOREPINEPHRINE L-BITARTRATE &
L-Noradrenaline Bitartrate Monohydrate>
L-(-)-Norepinephrine (bitartrate hydrate)
norepinephrine hydrogen tartrate monohydrate
(R)-(?-Norepinephrine L-bitartrate monohydrate
L-4-(A-HYDROXY-B-AMINOETHYL)CATECHOL BITARTRATE
Noradrenaline bitartrate Monohydrate (Levophed)
(R)-(-)-norepinephrine L-bitartrate monohydrate,
L-Arterenol Bitartrate
L-Norepinephrine Bitartrate
NOREPINEPHRINE BITARTRATE MONOHYDRATE*20 0 MG PER VI
L-(-)-Noradrenaline monohydrate (+)-bitartrate salt
L-(-)-Norepinephrine monohydrate (+)-bitartrate salt
L-()-Norepinephrine (+)-bitartrate salt monohydrate L-(-)-
R(-)-4-(2-AMINO-1-HYDROXYETHYL)-1,2-BENZENEDIOL-(+)-TARTRATE
Noradrenaline bitartrate（L-Noradrenaline bitartrate monohydrate）
）
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol (L-(+))-bitartrate salt
4-[(1R)-2-AMino-1-hydroxyethyl]-1,2-benzenediol Hydrogen Tartrate Monohydrate
4-[(1R)-2-amino-1-hydroxyethyl]-1,2-Benzenediol (2R,3R)-2,3-dihydroxybutanedioate hydrate (1:1:1)
1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, (2R,3R)-2,3-dihydroxybutanedioate, hydrate (1:1:1) | [EINECS(EC#)]
627-941-5 | [Molecular Formula]
C12H17NO9 | [MDL Number]
MFCD00036384 | [MOL File]
108341-18-0.mol | [Molecular Weight]
319.26 |
| Chemical Properties | Back Directory | [Melting point ]
100-104 °C(lit.)
| [refractive index ]
-11 ° (C=5, H2O) | [storage temp. ]
Refrigerator | [solubility ]
H2O: soluble50mg/mL, clear | [form ]
solid | [pka]
8.64(at 25℃) | [color ]
white | [optical activity]
[α]20/D 11.5±1°, c = 2% in H2O | [Water Solubility ]
water: 1mg/mL | [BRN ]
4078502 | [InChI]
InChI=1/C8H11NO3.C4H6O6/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-;1-,2-/s3 | [InChIKey]
WNPNNLQNNJQYFA-KBOIKTAVNA-N | [SMILES]
[C@H](C1C=CC(O)=C(O)C=1)(O)CN.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:0,12,17,r| |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A demethylated precursor of epinephrine. | [Uses]
Demethylated precursor of epinephrine (adrenaline). It is a sympathomimetic hormone produced by the adrenal gland. | [Uses]
Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.
Noradrenaline bitartrate monohydrate (Levophed) also directly stimulates the beta-adrenergic receptors of the heart (beta1-adrenergic receptors), but not th | [Biological Activity]
Adrenergic neurotransmitter. | [Biochem/physiol Actions]
Norepinephrine bitartrate plays an important role in in vivo and in vitro development of pathogenic and indigenous bacteria. It acts as a vasoconstrictor and adrenergic neurotransmitter. | [in vivo]
Norepinephrine bitartrate monohydrate can be used to induce cardiomyopathy[5][6]
Induced Cardiomyopathy Model[5][6] Background Norepinephrine bitartrate monohydrate is a potent growth factor for cardiomyocytes. Long-term infusion of subhyperbaric doses of Norepinephrine bitartrate monohydrate in animals can cause increases in myocardial mass and left ventricular wall thickness. Norepinephrine bitartrate monohydrate activates the Raf-1 kinase/MAP kinase cascade through α1- and β-adrenergic stimulation, and signaling pathways from both receptors synergistically induce cardiomyocyte hypertrophy.
Specific Modeling Methods
Rat: Spragues-Dawley rats ? adult (6 months old) ? male
Administration: Continuously injected via an osmotic minipump ? 100 μg/kg/h or 200 μg/kg/h (Norepinephrine)
Modeling Indicators Molecular changes: Left ventricular Dnmt activity ↑; ROS generation ↑; lactate dehydrogenase release ↑; dystrophin expression ↑; FHL2 protein expression ↓
Gene Expression: Expression of Dnmt1, 3a, and 3b ↑; mRNA expression of fetal genes ANP, BNP, and βMHC in left ventricle ↑
Phenotypic observation: Myocardial infarction area ↑; blood pressure continues to rise; left ventricular mass ↑; left ventricular development pressure ↓; cardiac contractility ↓. Cardiac hypertrophy.
Correlated Product(s): / Opposite Product(s): 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B) | [IC 50]
α1-adrenergic receptor; α2-adrenergic receptor; Beta-1 adrenergic receptor; Microbial Metabolite; Human Endogenous Metabolite | [storage]
4°C, protect from light, stored under nitrogen |
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