| Identification | Back Directory | [Name]
Wandonorm | [CAS]
82857-38-3 | [Synonyms]
LT 31-200
Wandonorm
Bopindolol hydrogen malonate
Propanedioic acid, compd. with 2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1)
Propanedioic acid, compd. with (+-)-2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1)
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), propanedioate (1:1) (salt) (9CI)
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), (+-)-, propanedioate (1:1) (salt) | [Molecular Formula]
C26H32N2O7 | [MDL Number]
MFCD00798228 | [MOL File]
82857-38-3.mol | [Molecular Weight]
484.541 |
| Hazard Information | Back Directory | [Uses]
Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research. | [Definition]
ChEBI: Bopindolol malonate is a benzoate ester. | [in vivo]
Bopindolol (intravenous injection; 8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs[1].
Bopindolol (0.3, 1 and 3 mg/kg; IP; single dosage) produces dose dependent decreases in diastolic blood pressure and in heart rate[2]. | Animal Model: | Male Wistar rats (260-300 g)[2] | | Dosage: | 0.3, 1 and 3 mg/kg | | Administration: | IP; single dosage | | Result: | Produced dose dependent decreases in diastolic blood pressure, and the decrease of about 8 mmHg at 3 mg/kg.
Decreased the heart rate in a dose-dependent manner. |
| [storage]
Store at -20°C | [References]
[1] Harron DW, et al. Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1991 Jan;41(1):130-49. DOI:10.2165/00003495-199141010-00010
[2] H Tanaka, et al. Hypotensive effect of bopindolol in pithed rats. Gen Pharmacol. 1993 Mar;24(2):373-5. DOI:10.1016/0306-3623(93)90319-s
[3] Y Hosohata, et al. Bopindolol is a slowly dissociating beta 1-adrenoceptor antagonist when compared to other beta-blockers. Biol Pharm Bull. 1995 Aug;18(8):1066-71. DOI:10.1248/bpb.18.1066
[4] Nagatomo T, et al. Bopindolol: pharmacological basis and clinical implications. Cardiovasc Drug Rev. 2001 Spring;19(1):9-24. DOI:10.1111/j.1527-3466.2001.tb00180.x |
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