| Identification | More | [Name]
3-(1-Piperidinylmethyl)phenol | [CAS]
73279-04-6 | [Synonyms]
1-(3-HYDROXYPHENYLMETHYL)PIPERIDINE
3-(1-PIPERIDINOMETHYL)PHENOL
3-(1-PIPERIDINYLMETHYL)PHENOL
4-(4-FLUOROBENZOYL)PIPERIDINE HCL
4-(4'-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE
4-(4-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE
4-FLUOROPHENYL 4-PIPERIDINYL METHANONE
(4-FLUOROPHENYL)(4-PIPERIDYL)METHANONE HYDROCHLORIDE
(4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANONE HYDROCHLORIDE
4-(P-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE
BUTTPARK 99\50-17
Piperidinol
3-(1-Piperidinyl)Phenol
3-(1-Piperidinyl
3-(piperidin-1-ylmethyl)phenol
3-(Piperidinomethyl)phenol
m-(Piperidinomethyl)phenol | [Molecular Formula]
C12H17NO | [MDL Number]
MFCD00044912 | [Molecular Weight]
191.27 | [MOL File]
73279-04-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
137-138°C | [Boiling point ]
308.1±17.0 °C(Predicted) | [density ]
1.097±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
9.97±0.10(Predicted) | [color ]
White to Almost white | [InChI]
InChI=1S/C12H17NO/c14-12-6-4-5-11(9-12)10-13-7-2-1-3-8-13/h4-6,9,14H,1-3,7-8,10H2 | [InChIKey]
ORGBERFQYFWYGX-UHFFFAOYSA-N | [SMILES]
C1(O)=CC=CC(CN2CCCCC2)=C1 | [CAS DataBase Reference]
73279-04-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Synthesis]
In a three-necked flask equipped with a stirrer, condenser tube and thermometer, add 2.4 g of m-hydroxybenzaldehyde dissolved in 40 mL of formic acid with stirring. The temperature was controlled to be below 60 °C and 4.2 g of hexahydropyridine was slowly added dropwise. After the dropwise addition was completed, the temperature was raised to 110 °C and the reaction was refluxed for 2 h (the progress of the reaction was monitored by thin layer chromatography). Upon completion of the reaction, the reaction solution was diluted with 150 mL of water and cooled to 15 °C. Decolorization was carried out by adding 0.1 g of activated carbon and filtered. The pH of the filtrate was adjusted with 12% ammonia to 8.5. allowed to stand and crystallized at 10 °C. The crystals were collected by filtration, washed with cold water and dried to give Intermediate III-1 (3-(1-piperidinylmethyl)phenol) 3.0 g as yellow crystals in 78% yield. | [References]
[1] Arzneimittel-Forschung/Drug Research, 1985, vol. 35, # 7, p. 1025 - 1029
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 4, p. 989 - 994
[3] ChemMedChem, 2015, vol. 10, # 1, p. 83 - 93
[4] Patent: CN103626722, 2016, B. Location in patent: Paragraph 0049-0052
[5] Synthetic Communications, 1999, vol. 29, # 1, p. 15 - 20 |
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