| Identification | Back Directory | [Name]
TAS-102 | [CAS]
733030-01-8 | [Synonyms]
TAS-102
TAS 102 (2:1)
TAS102; TAS 102
TAS-102 (LONSURF)
TAS-102(TIPIRACIL, TRIFLURIDINE)
Trifluridine-tipiracil hydrochloride mixt.
Tipiracil hydrochloride-trifluridine mixt.
TRIFLURIDINE-TIPIRACIL HYDROCHLORIDE MIXTURE
TAS-102(Tipiracil hydrochloride-trifluridine mixt) | [Molecular Formula]
C19H23Cl2F3N6O7 | [MDL Number]
MFCD30481309 | [MOL File]
733030-01-8.mol | [Molecular Weight]
575.323 |
| Chemical Properties | Back Directory | [Melting point ]
170-172°C | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly, Heated, Sonicated), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
TAS 102 (Tipiracil-trifluridine) is a thymidine phosphorylase inhibitor used in chemotherapy treatment of advanced/recurring colorectal cancer. | [Biological Activity]
Anti cancerAnti angiogenic | [in vivo]
Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models[2]. | Animal Model: | Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells[2] | | Dosage: | 150 mg/kg/day | | Administration: | p.o.; twice a day for 14 days | | Result: | Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models. |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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