| Identification | Back Directory | [Name]
3,5-Pyridinedicarbonitrile, 2-amino-4-(4-hydroxyphenyl)-6-(phenylthio)- | [CAS]
735273-33-3 | [Synonyms]
α-Glucosidase-IN-9
3,5-Pyridinedicarbonitrile, 2-amino-4-(4-hydroxyphenyl)-6-(phenylthio)- | [Molecular Formula]
C19H12N4OS | [MOL File]
735273-33-3.mol | [Molecular Weight]
344.39 |
| Chemical Properties | Back Directory | [Melting point ]
314 °C(Solv: acetonitrile (75-05-8)) | [Boiling point ]
630.5±55.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [pka]
6.65±0.15(Predicted) |
| Hazard Information | Back Directory | [Uses]
α-Glucosidase-IN-9 (compound 7) is a potent α-glucosidase inhibitor, with an IC50 of 55.6 μM. α-Glucosidase-IN-9 can be used for type II diabetes research[1]. | [IC 50]
Glucosidase | [References]
[1] Ali M, et al. Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel α-glucosidase inhibitors. Bioorg Chem. 2020 Jul;100:103879. DOI:10.1016/j.bioorg.2020.103879 |
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