ChemicalBook--->CAS DataBase List--->73681-12-6

73681-12-6

73681-12-6 Structure

73681-12-6 Structure
IdentificationBack Directory
[Name]

Indecainid
[CAS]

73681-12-6
[Synonyms]

Decabid
LY 135837
Indecainid
9-(3-(isopropylamino)propyl)-9H-fluorene-9-carboxamide hydrochloride
[Molecular Formula]

C20H25ClN2O
[MDL Number]

MFCD01726598
[MOL File]

73681-12-6.mol
[Molecular Weight]

344.878
Chemical PropertiesBack Directory
[Melting point ]

216.5-217°; mp 203-204°
Hazard InformationBack Directory
[Uses]

Cardiac depressant (anti-arrhythmic).
[Uses]

Indecainide Hydrochloride is a pharmaceutical analog that is used in the treatment of cardiac antiarrhythmias.
[Brand name]

Decabid (Lilly).
[in vivo]

Indecainide hydrochloride (0, 3, 6, or 9 mg/kg; IV, daily for 1 month) causes 6 of 10 male rats and 1 of 10 female rats die at 9 mg/kg during the test period[2].
Indecainide hydrochloride (0, 1.5, 3, or 4.5 mg/kg; IV, daily for 1 month) causes 2 of 4 dogs die at 4.5 mg/kg; exhibits no overt signs of toxicity and no hematologic, serum chemistry or histologic changes at 1.5 or 3 mg/kg[2].

Safety DataBack Directory
[Toxicity]

LD50 orally in male, female mice, rats: 100, 96, 103, 82 mg/kg (Sandusky, Meyers)
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