| Identification | More | [Name]
GLYCYL-L-GLUTAMIC ACID | [CAS]
7412-78-4 | [Synonyms]
BETA-ENDORPHIN (30-31) (HUMAN)
BETA-LIPOTROPIN (88-89) (HUMAN)
BETA-LIPOTROPIN (90-91) (HUMAN)
GLYCYL-L-GLUTAMIC ACID
GLY-GLU
H-GLY-GLU-OH
L-Glutamic acid, N-glycyl-
N-(Aminoacetyl)glutamic acid
N-glycyl-L-glutamic acid
N-glycylglutamic acid
Gly-Glu-OH
Gly-L-Glu-OH | [EINECS(EC#)]
231-019-4 | [Molecular Formula]
C7H12N2O5 | [MDL Number]
MFCD00008128 | [Molecular Weight]
204.18 | [MOL File]
7412-78-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
155-158 °C (dec.)(lit.) | [Boiling point ]
342.66°C (rough estimate) | [density ]
1.4123 (rough estimate) | [refractive index ]
1.4880 (estimate) | [storage temp. ]
−20°C
| [form ]
powder to crystal | [pka]
3.02±0.10(Predicted) | [color ]
White to Almost white | [Water Solubility ]
very faint turbidity | [InChI]
1S/C7H12N2O5/c8-3-5(10)9-4(7(13)14)1-2-6(11)12/h4H,1-3,8H2,(H,9,10)(H,11,12)(H,13,14)/t4-/m0/s1 | [InChIKey]
IEFJWDNGDZAYNZ-BYPYZUCNSA-N | [SMILES]
NCC(=O)N[C@@H](CCC(O)=O)C(O)=O | [CAS DataBase Reference]
7412-78-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29224985 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration[1][2]. | [Definition]
ChEBI: A dipeptide formed from glycyl and L-glutamic acid residues. | [References]
[1] Koelle GB, et al. Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Proc DOI:10.1073/pnas.82.15.5213
[2] Yourick JJ, et al. Regeneration of acetylcholinesterase in clonal neuroblastoma-glioma hybrid NG108-15 cells after soman inhibition: effect of glycyl-L-glutamine. Cell Biol Toxicol. 1991 Jul;7(3):229-37. DOI:10.1007/BF00250977 |
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