| Identification | More | [Name]
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid | [CAS]
74163-81-8 | [Synonyms]
3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-,(3S)-
L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
L-TIC HCL
(S)-1,2,3,4-TETRAHYDO-3-ISOQUINOLINECARBOXYLIC ACID HCL
(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HCL SALT
(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE
(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HCL
S-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxlicacid
L-1,2,3,4-Tetrahydroisoquinoline-3-CarboxylicAcid98%
(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYLESTHER
(3S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLICACIDHYDROCHLORIDE
L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC
(S)-1,2,3,4-Tetrahydro-3-isoquinoline-carboxylic aci
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
1,2,3,4-Tetrahydroisoquinoline-3-carboxxylic acid
(S)-1,2,3,4-TERTRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID
(S)-TIC
(S)-N-tert-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | [EINECS(EC#)]
616-058-0 | [Molecular Formula]
C10H11NO2 | [MDL Number]
MFCD00800357 | [Molecular Weight]
177.2 | [MOL File]
74163-81-8.mol |
| Questions And Answer | Back Directory | [Description]
(S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a quinoline derivative, which is used as an intermediate in the synthesis of quinapril. Quinapril, a product developed by Pfizer, was approved by the US FDA in 1991 for the treatment of hypertension, congestive heart failure and angioedema. |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
>300 °C(lit.) | [alpha ]
-157.4 º (24 ºC) | [Boiling point ]
309.12°C (rough estimate) | [density ]
1.1607 (rough estimate) | [refractive index ]
-166 ° (C=1, 1mol/L NaOH) | [storage temp. ]
Store at 0-5°C | [solubility ]
soluble in Hot Water, Basic Water | [form ]
powder to crystal | [pka]
2.21±0.20(Predicted) | [color ]
White to Almost white | [Optical Rotation]
[α]20/D 168°, c = 1.8 in 1.4 M NaOH | [BRN ]
4842199 | [InChIKey]
BWKMGYQJPOAASG-VIFPVBQESA-N | [CAS DataBase Reference]
74163-81-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29334900 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Quinapril EP Impurity A) is a Quinapril intermediate. | [Uses]
Quinapril intermediate. | [reaction suitability]
reaction type: solution phase peptide synthesis |
| Well-known Reagent Company Product Information | Back Directory | [Acros Organics]
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, 98%(74163-81-8) | [Alfa Aesar]
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, 97%(74163-81-8) | [Sigma Aldrich]
74163-81-8(sigmaaldrich) | [TCI AMERICA]
(S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid,>95.0%(T)(74163-81-8) |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 18918157536; |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
Adamas Reagent, Ltd.
|
| Telephone: |
4006009262 13023226327 |
| Website: |
http://www.tansoole.com |
|