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109-99-9

109-99-9 Structure

109-99-9 Structure
IdentificationMore
[Name]

Tetrahydrofuran
[CAS]

109-99-9
[Synonyms]

ALPHA-HYDRO-OMEGA-HYDROXYPOLY(OXY-1,4-BUTANEDIYL)
POLY(1,4-BUTANEDIOL)
POLY(1,4-OXYBUTYLENE) GLYCOL
POLYETETRAHYDROFURAN, LINEAR-CHAIN POLYMER
POLYLETRAHYDROFURAN, LINEAR CHAIN POLYMER
POLYTETRAHYDROFURAN
POLYTETRAHYDROFURAN 1000
POLYTETRAHYDROFURAN 1000 S
POLYTETRAHYDROFURAN 1400
POLYTETRAHYDROFURAN 1800
POLYTETRAHYDROFURAN 2000
POLYTETRAHYDROFURAN 250
POLYTETRAHYDROFURAN 650 S
POLYTETRAHYDROFURAN, LINEAR-CHAIN POLYMER
POLY(TETRAMETHYLENE ETHER) GLYCOL
POLYTETRAMETHYLENE ETHER GLYCOL 1000
POLYTETRAMETHYLENE ETHER GLYCOL 1000 S
POLYTETRAMETHYLENE ETHER GLYCOL 1400
POLYTETRAMETHYLENE ETHER GLYCOL 1800
POLYTETRAMETHYLENE ETHER GLYCOL 2000
[EINECS(EC#)]

203-786-5
[Molecular Formula]

C4H8O
[MDL Number]

MFCD00148879
[Molecular Weight]

72.11
[MOL File]

109-99-9.mol
Chemical PropertiesBack Directory
[Description]

Tetrahydrofuran (THF) is a chemical intermediate used in the manufacture of polymers as well as agricultural, pharmaceutical, and commodity chemicals. Manufacturing activities commonly occur in closed systems or under engineering controls that limit worker exposure and release to the environment. THF is also used as a solvent (e.g., pipe fitting) that may result in more significant exposures when used in confined spaces without sufficient ventilation. Although THF is naturally present in coffee aroma, floured chickpeas, and cooked chicken, natural exposures are not anticipated to pose a significant hazard.
[Appearance]

Tetrahydrofuran is a colorless liquid. Ethereal odor. The Odor Threshold is listed @ 3.8 (3M), 20-50 ppm, and 31 ppm.
[Appearance]

Colorless liquid
[mp ]

33-36 °C
[bp ]

66 °C
[density ]

0.887 g/mL at 20 °C
[vapor density ]

2.5 (vs air)
[vapor pressure ]

<0.01 mm Hg ( 25 °C)
[refractive index ]

n20/D 1.465
[Fp ]

>230 °F
[storage temp. ]

2-8°C
[color ]

<10(APHA)
[Stability:]

Stable. Incompatible with halogens, strong oxidizing agents, strong reducing agents, strong bases, oxygen. May generate explosive peroxides in storage if in contact with air. Highly flammable. Store at room temperature under nitrogen. Hazardous polymerisation may occur. Light sensitive. May contain 2,6-di-tertbutyl-4-methylphenol (BHT) as a s
[Water Solubility ]

miscible
[FreezingPoint ]

-108℃
[Sensitive ]

Air Sensitive & Hygroscopic
[Detection Methods]

GC
[Merck ]

14,9211
[BRN ]

102391
[Uses]

Tetrahydrofuran is used primarily (80%) to make polytetramethylene ether glycol, the base polymer used primarily in the manufacture of elastomeric fibers (e.g., spandex) as well as polyurethane and polyester elastomers (e.g., artificial leather, skateboard wheels). The remainder (20%) is used in solvent applications (e.g., pipe cements, adhesives, printing inks, and magnetic tape) and as a reaction solvent in chemical and pharmaceutical syntheses.
[CAS DataBase Reference]

109-99-9(CAS DataBase Reference)
[NIST Chemistry Reference]

Furan, tetrahydro-(109-99-9)
[Storage Precautions]

Moisture sensitive;Light sensitive
[EPA Substance Registry System]

109-99-9(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xi,F,Xn
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
R36/37:Irritating to eyes and respiratory system .
R19:May form explosive peroxides.
R11:Highly Flammable.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S33:Take precautionary measures against static discharges .
S29:Do not empty into drains .
S16:Keep away from sources of ignition-No smoking .
[RIDADR ]

UN 2924 3/PG 2
[WGK Germany ]

1
[RTECS ]

MD0916000
[F ]

3-10-23
[HazardClass ]

3
[PackingGroup ]

II
[HS Code ]

29321100
[Safety Profile]

Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects by inhalation: general anesthesia. Mutation data reported. Irritant to eyes and mucous membranes. Narcotic in high concentrations. Reported as causing injury to liver and kidneys. Flammable liquid. A very dangerous fire hazard when exposed to heat, flames, oxidizers. Explosive in the form of vapor when exposed to heat or flame. In common with ethers, unstabilized tetrahydrofuran forms thermally explosive peroxides on exposure to air. Stored THF must always be tested for peroxide prior to distdlation. Peroxides can be removed by treatment with strong ferrous sulfate solution made slightly acidic with sodium bisulfate. Caustic alkalies deplete the inhibitor in THF and may subsequently cause an explosive reaction. Explosive reaction with KOH, NaAlH2, NaOH, sodium tetrahydroaluminate. Reacts with 2-aminophenol + potassium dioxide to form an explosive product. Reacts with lithium tetrahydroaluminate or borane to form explosive hydrogen gas. Violent reaction with metal halides (e.g., hafnium tetrachloride, titanium tetrachloride, zirconium tetrachloride). Vigorous reaction with bromine, calcium hydride + heat. Can react with oxidizing materials. To fight fire, use foam, dry chemical, COa. When heated to decomposition it emits acrid smoke and irritating fumes. See also 2TETRAHYDROFURYL HYDROPEROXIDE
[Hazardous Substances Data]

109-99-9(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Hydrogen-->Nickel-->gamma-Butyrolactone-->1,4-Butanediol-->Polychloroprene-->2-CHLORO-1,3-BUTADIENE-->Metallic oxides-->PALLADIUM-CATALYSTS-->cis-1,4-Dichloro-2-butene-->IRISH MOSS
[Preparation Products]

N-(2-Aminoethyl)piperidine-->Cyclopropylacetic acid-->2,3-Difluorophenylboronic acid-->3-Cyanophenylboronic acid-->(4-AMINO-PYRIDIN-3-YL)-METHANOL-->BENZO[B]THIOPHENE-2-CARBOXALDEHYDE-->alpha,alpha-Diphenyl-L-prolinol-->L-Tryptophanol-->2,3,4-Tribromothiophene-->2-(4-tert-Butylphenyl)ethanol-->3-tert-butyl-1H-1,2,4-triazole-5-thiol -->Erythromycin ethylsuccinate -->L(+)-Leucinol-->2-Chloroisonicotinaldehyde-->4-TERT-BUTYLBENZYL ALCOHOL-->Dioctyl(maleate)tin -->Chiral 2,2-Disubstituted thiaprolinol derivatives-->1,4-Butane sultone-->2,2'-DIPYRIDYLAMINE-->Benzyldimethylhexadecylammonium chloride-->4-Amino-5-bromo-2-chloropyrimidine-->SODIUM PHENOLATE TRIHYDRATE-->1-(2-NAPHTHYL)METHANAMINE-->Vinylferrocene-->(R)-TERT-LEUCINOL-->(1,5-DIMETHYL-1H-PYRAZOL-3-YL)METHANOL-->9-Anthracenemethanol-->7-Fluoroindole-->(S)-(-)-4-tert-Butyloxazolidine-2,5-dione-->TERT-BUTYLMAGNESIUM CHLORIDE-->2,5-Dimethylpiperazine-->Allylmagnesium chloride-->Norethindrone-->Levonorgestrel-->4-Chlorobutylbenzoate-->Quinestrol-->Jiuma plate amino-acid surfactant-->1,4-Diiodobutane-->N-methylaminoethanol sodium phosphate-->Tetrahydrothiophene
Hazard InformationBack Directory
[General Description]

A clear colorless liquid with an ethereal odor. Less dense than water. Flash point 6°F. Vapors are heavier than air.
[Reactivity Profile]

TETRAHYDROFURAN(109-99-9) reacts violently with oxidizing agents leading to fires and explosions [Handling Chemicals Safely 1980. p. 891]. Subject to peroxidation in the air. Peroxides or their products react exothermically with lithium aluminum hydride [MCA Guide for Safety 1973]. Thus, use as a solvent for lithium aluminum hydride has led to fires. Using potassium hydroxide or sodium hydroxide to dry impure TETRAHYDROFURAN(109-99-9) that contains peroxides has resulted in explosions. A violent explosion occurred during the preparation of sodium aluminum hydride from sodium and aluminum in a medium of TETRAHYDROFURAN(109-99-9) [Chem. Eng. News 39(40):57. 1961]. THF forms explosive products with 2-aminophenol [Lewis 3227].
[Air & Water Reactions]

Highly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Soluble in water.
[Health Hazard]

Vapors cause nausea, dizziness, headache, and anesthesia. Liquid can de-fat the skin and cause irritation. Liquid also irritates eyes.
[Potential Exposure]

The primary use of tetrahydrofuran is as a solvent to dissolve synthetic resins, particularly polyvinyl chloride and vinylidene chloride copolymers. It is also used to cast polyvinyl chloride films, to coat substrates with vinyl and vinylidene chloride; and to solubilize adhesives based on or containing polyvinyl chloride resins. A second large market for THF is as an electrolytic solvent in the Grignard reaction-based production of tetramethyl lead. THF is used as an intermediate in the production of polytetramethylene glycol.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
[Shipping]

UN2056 Tetrahydrofuran, Hazard Class: 3; Labels: 3-Flammable liquid.
[Incompatibilities]

Forms thermally explosive peroxides in air on standing (in absence of inhibitors). Peroxides can be detonated by heating, friction, or impact. Reacts violently with strong oxidizers, strong bases and some metal halides. Attacks some forms of plastics, rubber and coatings.
[Waste Disposal]

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Concentrated waste containing peroxides-perforation of a container of the waste from a safe distance followed by open burning.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

1,4-Epoxybutane(109-99-9).msds
Spectrum DetailBack Directory
[Spectrum Detail]

Tetrahydrofuran(109-99-9)MS
Tetrahydrofuran(109-99-9)1HNMR
Tetrahydrofuran(109-99-9)13CNMR
Tetrahydrofuran(109-99-9)Raman
Tetrahydrofuran(109-99-9)IR1
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Tetrahydrofuran, stabilized with BHT, for analysis ACS, 99.6%(109-99-9)
[Alfa Aesar]

Tetrahydrofuran, UV, HPLC Grade, 99.7+% min, unstab.(109-99-9)
[Sigma Aldrich]

109-99-9(sigmaaldrich)
[TCI AMERICA]

Tetrahydrofuran  Anhydrous (stabilized with BHT),>98.0%(GC)(109-99-9)
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