Identification | Back Directory | [Name]
ALPHA-DENDROTOXIN | [CAS]
74504-53-3 | [Synonyms]
ALPHA-DTX a-Dendrotoxin α-Dendrotoxin ALPHA-DENDROTOXIN toxin C(13)S(2)C(3) A-dendrotoxin from dendroaspis*angusticeps α-dendrotoxin from dendroaspis angusticeps (eastern green mamba) PYR-PRO-ARG-ARG-LYS-LEU-CYS-ILE-LEU-HIS-ARG-ASN-PRO-GLY-ARG-CYS-TYR-ASP-LYS-ILE-PRO-ALA-PHE-TYR-TYR-ASN-GLN-LYS-LYS-LYS-GLN-CYS-GLU-ARG-PHE-ASP-TRP-SER-GLY-CYS-GLY-GLY-ASN-SER-ASN-ARG-PHE-LYS-THR-ILE-GLU-GLU-CYS-ARG-ARG-THR-CYS-ILE-GLY-OH Alpha-Dendrotoxin Pyr-Pro-Arg-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Asp-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Arg-Phe-Asp-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Gly-OH (Disulfide bonds between Cys7 and Cys57/Cys16 and Cys40/Cys32 and Cys53) | [Molecular Formula]
C305H480N98O85S6 | [MDL Number]
MFCD00162007 | [MOL File]
74504-53-3.mol | [Molecular Weight]
7072.07 |
Chemical Properties | Back Directory | [storage temp. ]
−20°C | [form ]
Lyophilized solid. | [Sequence]
{Pyr}-Pro-Arg-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Asp-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Arg-Phe-Asp-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Gly (disulfide bridge:Cys7-Cys57,Cys16-Cys40,Cys32-Cys53) |
Hazard Information | Back Directory | [Uses]
α-Dendrotoxin (α-DTX) is a small molecule peptide neurotoxin isolated from the venom of the African green mamba snake (Dendroaspis angusticeps). α-Dendrotoxin is also a KV1.1, KV1.2, KV1.6 and ASIC channel blocker. α-Dendrotoxin blocks potassium channels, lowers the threshold of neuronal action potentials, and increases the frequency of action potentials, thereby enhancing neuronal excitability. α-Dendrotoxin can be used in neurotoxicology research[1]. | [References]
[1] Bekkers J M, et al. Modulation of excitability by α-dendrotoxin-sensitive potassium channels in neocortical pyramidal neurons[J]. Journal of Neuroscience, 2001, 21(17): 6553-6560. DOI:10.1523/JNEUROSCI.21-17-06553.2001 |
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