ChemicalBook--->CAS DataBase List--->74504-53-3

74504-53-3

74504-53-3 Structure

74504-53-3 Structure
IdentificationBack Directory
[Name]

ALPHA-DENDROTOXIN
[CAS]

74504-53-3
[Synonyms]

ALPHA-DTX
a-Dendrotoxin
α-Dendrotoxin
ALPHA-DENDROTOXIN
toxin C(13)S(2)C(3)
A-dendrotoxin from dendroaspis*angusticeps
α-dendrotoxin from dendroaspis angusticeps (eastern green mamba)
PYR-PRO-ARG-ARG-LYS-LEU-CYS-ILE-LEU-HIS-ARG-ASN-PRO-GLY-ARG-CYS-TYR-ASP-LYS-ILE-PRO-ALA-PHE-TYR-TYR-ASN-GLN-LYS-LYS-LYS-GLN-CYS-GLU-ARG-PHE-ASP-TRP-SER-GLY-CYS-GLY-GLY-ASN-SER-ASN-ARG-PHE-LYS-THR-ILE-GLU-GLU-CYS-ARG-ARG-THR-CYS-ILE-GLY-OH
Alpha-Dendrotoxin Pyr-Pro-Arg-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Asp-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Arg-Phe-Asp-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Gly-OH (Disulfide bonds between Cys7 and Cys57/Cys16 and Cys40/Cys32 and Cys53)
[Molecular Formula]

C305H480N98O85S6
[MDL Number]

MFCD00162007
[MOL File]

74504-53-3.mol
[Molecular Weight]

7072.07
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[form ]

Lyophilized solid.
[Sequence]

{Pyr}-Pro-Arg-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Asp-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Arg-Phe-Asp-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Gly (disulfide bridge:Cys7-Cys57,Cys16-Cys40,Cys32-Cys53)
Safety DataBack Directory
[Hazard Codes ]

T+
[Risk Statements ]

28
[Safety Statements ]

28-36/37-45
[RIDADR ]

UN 2811 6.1/PG 1
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

α-Dendrotoxin (α-DTX) is a small molecule peptide neurotoxin isolated from the venom of the African green mamba snake (Dendroaspis angusticeps). α-Dendrotoxin is also a KV1.1, KV1.2, KV1.6 and ASIC channel blocker. α-Dendrotoxin blocks potassium channels, lowers the threshold of neuronal action potentials, and increases the frequency of action potentials, thereby enhancing neuronal excitability. α-Dendrotoxin can be used in neurotoxicology research[1].
[References]

[1] Bekkers J M, et al. Modulation of excitability by α-dendrotoxin-sensitive potassium channels in neocortical pyramidal neurons[J]. Journal of Neuroscience, 2001, 21(17): 6553-6560. DOI:10.1523/JNEUROSCI.21-17-06553.2001
74504-53-3 suppliers list
Company Name: Nanjing TGpeptide
Tel: +86-13347807150
Website: tgpeptides.com/index.aspx
Company Name: Changsha MOL Changes Biotechnology Co., Ltd.
Tel: +8619375158599 , +8619375158599
Website: www.molchanges.com
Company Name: Shanghai Hanhong Scientific Co.,Ltd.  
Tel: 021-54306202 13764082696
Website: https://www.hanhongsci.com
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Website: www.shchemsky.com
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Website: https://www.bocsci.com
Company Name: Shenzhen Regent Biochemical Technology Co., Ltd.  
Tel: 0755-85201366 18938635012
Website: http://www.regentsciences.com/
Company Name: Hangzhou Peptidego Biotech Co.,Ltd.  
Tel: 0571-87213919
Website: http://peptidego.com
Company Name: Nanjing TGpeptide Biotechnology Co.,Ltd.  
Tel: 18115476705
Website: http://www.tgpeptide.com/Index.aspx
Company Name: TCI (Shanghai) Chemical Trading Co., Ltd.  
Tel: 021-61109150
Website: www.tcisct.com
Company Name: Shaoxing Junyu Biotechnology Co., LTD  
Tel: 0571-0571-88211921 19105816207
Website: www.gotopbio.com/
Company Name: Shanghai HongTide Biotechnology Co.,Ltd.  
Tel: 15318089928
Website: https://www.hongtide.com/index.php
Company Name: https://hanhongsci.com/  
Tel: 021-54306202 18917919676
Website: https://www.hanhongsci.com/
Company Name: Zhejiang Jiekun Biotechnology Co., Ltd  
Tel: 0571-88211951 13735575465
Website: www.gotopbio.com/
Company Name: Taiyuan Bailihengkang Biotechnology Co., Ltd  
Tel: 19135651983
Website: http://www.blhkpharm.com/
Company Name: Enzo Biochem Inc  
Tel: Enzo Biochem Inc. 13797054060
Website: www.enzo.com
Company Name: Alomone Labs  
Tel: 4008-168-068 13121892008
Website: www.alomone.com
Company Name: Biosynth Biological Technology (Suzhou) Co Ltd  
Tel: 51288865780
Website: www.biosynth.com
Company Name: Santa Cruz Biotechnology Inc  
Tel: 021-60936350
Website: www.scbt.com
Tags:74504-53-3 Related Product Information
93839-89-5 24345-16-2 12627-35-9 448895-37-2 57568-80-6 289905-88-0 71186-53-3 92953-10-1 64744-50-9 57186-25-1 10238-21-8 65141-46-0 95751-30-7 121055-10-5 113558-89-7 147695-92-9

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.