ChemicalBook--->CAS DataBase List--->74611-28-2

74611-28-2

74611-28-2 Structure

74611-28-2 Structure
IdentificationBack Directory
[Name]

METHIOTHEPIN MESYLATE SEROTININ 5-HT(1) ANT
[CAS]

74611-28-2
[Synonyms]

Ro 8-6837 mesylate
Metitepine mesylate salt
methiothepin mesylate salt
METHIOTHEPIN MESYLATE SEROTININ 5-HT(1) ANT
1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt
Metitepine mesylate salt, 1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt
[Molecular Formula]

C20H24N2S2CH3SO3H
[MDL Number]

MFCD00153831
[MOL File]

74611-28-2.mol
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

H2O: soluble13mg/mL
[form ]

solid
[color ]

white
[Water Solubility ]

H2O: 13mg/mL
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.
[General Description]

Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.
[Biochem/physiol Actions]

Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
[IC 50]

5-HT1A Receptor: 7.10 (pKd); 5-HT1B Receptor: 7.28 (pKd); 5-HT1C Receptor: 7.56 (pKd); 5-HT1D Receptor: 6.99 (pKd); 5-HT5A Receptor: 7.0 (pKd); 5-HT5B Receptor: 7.8 (pKd); 5-HT6 Receptor: 8.74 (pKd); 5-HT7 Receptor: 8.99 (pKd); 5-HT2A Receptor: 8.50 (pKi); 5-HT2B Receptor: 8.68 (pKi); 5-HT2C Receptor: 8.35 (pKi)
Spectrum DetailBack Directory
[Spectrum Detail]

METHIOTHEPIN MESYLATE SEROTININ 5-HT(1) ANT(74611-28-2)1HNMR
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