| Identification | More | [Name]
L-Prolinamide | [CAS]
7531-52-4 | [Synonyms]
2-PYRROLIDINECARBOXAMIDE, (2S)-
H-PRO-NH2
L-(-)-PROLINAMIDE
L-PROLINAMIDE
L-PROLINE AMIDE
L-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE
PROLINAMIDE
PROLINE-NH2
(S)-PROLINAMIDE
(S)-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE
(s)-(-)-pyrrolidin-2-carbonsaeureamid
(S)-pyrrolidine-2-carboxamide
L-PROLINAMIDE FREE BASE
Pro-Nh2
L-PROLINAMIDE 99.0%
H-Pro-NH2, free base
H-L-Pro-NH2
(S)-2-Pyrrolidinecarboxamide
L-Srolinamide, 98%
L-Pro-NH2 | [EINECS(EC#)]
231-397-0 | [Molecular Formula]
C5H10N2O | [MDL Number]
MFCD00005253 | [Molecular Weight]
114.15 | [MOL File]
7531-52-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline | [Melting point ]
95-97 °C (lit.) | [alpha ]
-106 º (c=2, EtOH) | [Boiling point ]
213.66°C (rough estimate) | [density ]
1.1008 (rough estimate) | [refractive index ]
1.4720 (estimate) | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Powder or Granules | [pka]
16.21±0.20(Predicted) | [color ]
White to straw | [Optical Rotation]
[α]20/D 106°, c = 2 in ethanol | [Water Solubility ]
Soluble in water and ethanol (50 mg/ml). | [Detection Methods]
GC | [BRN ]
80807 | [Major Application]
peptide synthesis | [InChI]
1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m0/s1 | [InChIKey]
VLJNHYLEOZPXFW-BYPYZUCNSA-N | [SMILES]
NC(=O)[C@@H]1CCCN1 | [CAS DataBase Reference]
7531-52-4(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Synthesis]
20% Pd(OH)₂/C (Pearlman catalyst, 80 mg) was added to a solution of the aminoamide adduct (175 mg, 0.8 mmol) in an EtOH/AcOH (1:1) (4 mL) mixture. The mixture was stirred at room temperature under H₂ (1 atm) for 14 hours. The mixture was degassed under an argon flow and filtered through diatomaceous earth. The collected solids were washed with EtOH (3 x 10 mL). The combined filtrate and washes were concentrated. The residue was neutralized with concentrated NH₄OH (2 mL). The mixture was placed in FC (eluent, MeOH/CH₂Cl₂/concentrated NH₄OH 50/50/1) to give L-prolylamide.
 Figure 1 Synthetic route of L-Prolinamide |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H317-H319 | [Precautionary statements ]
P261-P271-P280 | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [F ]
10 | [REACH Registrations]
Active | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline | [Uses]
Proline based organocatalyst. | [Definition]
ChEBI: The carboxamide derivative of L-proline. | [reaction suitability]
reaction type: solution phase peptide synthesis |
|
| Company Name: |
J & K SCIENTIFIC LTD. Gold
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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