| Identification | Back Directory | [Name]
1,4-Butanedione, 1-(4-chlorophenyl)-4-(4-cyclopentyl-1-piperazinyl)- | [CAS]
757183-18-9 | [Synonyms]
NNC381049
NNC-381049
NNC 381049
NNC38-1049
NNC 38-1049
NNC-38-1049
1,4-Butanedione, 1-(4-chlorophenyl)-4-(4-cyclopentyl-1-piperazinyl)- | [Molecular Formula]
C19H25ClN2O2 | [MOL File]
757183-18-9.mol | [Molecular Weight]
348.87 |
| Chemical Properties | Back Directory | [Boiling point ]
532.2±50.0 °C(Predicted) | [density ]
1.217±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.49±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NNC 38-1049 is an orally active, potent and competitive histamine H3 receptor antagonist. NNC 38-1049 produced an increase in extracellular levels of histamine in the paraventricular nucleus. NNC 38-1049 decreases food intake and body weight, which is promising for research of obesity[1]. | [References]
[1] Malml?f K, et al. Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight. Int J Obes (Lond). 2005 Dec;29(12):1402-12. DOI:10.1038/sj.ijo.0803036 |
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