| Identification | More | [Name]
2,2,6,6-Tetramethylpiperidine | [CAS]
768-66-1 | [Synonyms]
2,2,6,6-TETRAMETHYLPIPERIDINE
HTMP
2,2,6,6-tetramethyl-piperidin
Norpempidine
2,2,6,6-TETRAMETHYLPIPERIDINE, 99+%
2,2,6,6-Tetramethylpiperidien
TETRAMETHYLPIPERIDINE
Piperidine, 2,2,6,6-tetramethyl-
2,2,6,6-tetramethylpiperidine(TEMP)
2,2,6,6-Tetramethylpiperidine (HTMP)
2,2,6,6-Tetramethylpiperidine, 98+% | [EINECS(EC#)]
212-199-3 | [Molecular Formula]
C9H19N | [MDL Number]
MFCD00005985 | [Molecular Weight]
141.25 | [MOL File]
768-66-1.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to light yellow-green liquid | [Melting point ]
-59°C | [Boiling point ]
152 °C (lit.) | [density ]
0.837 g/mL at 25 °C(lit.)
| [vapor pressure ]
14 hPa (39 °C) | [refractive index ]
n20/D 1.445(lit.)
| [Fp ]
76 °F
| [storage temp. ]
Flammables area | [solubility ]
MISCIBLE | [form ]
Liquid | [pka]
11.07(at 25℃) | [color ]
Clear colorless to yellow | [Specific Gravity]
0.837 | [Water Solubility ]
MISCIBLE | [Sensitive ]
Air Sensitive | [Detection Methods]
GC,NMR | [BRN ]
103296 | [InChIKey]
RKMGAJGJIURJSJ-UHFFFAOYSA-N | [CAS DataBase Reference]
768-66-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Piperidine, 2,2,6,6-tetramethyl-(768-66-1) | [EPA Substance Registry System]
768-66-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,F,C | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1992 3/PG 3
| [WGK Germany ]
2
| [RTECS ]
TN4220000
| [Autoignition Temperature]
290 °C | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29333999 | [Toxicity]
LD50 orally in Rabbit: 500 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Preparation Products]
2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE-->5-FLUORO-2-PICOLINIC ACID-->2-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID-->2,2,6,6-Tetramethylpiperidinooxy-->3-BROMO-2-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE-->6-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID-->4-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-CHLORO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-BROMO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->3-FLUORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-(3-METHOXYPHENYL)CYCLOHEXANONE-->5-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-CYANO-5-BROMOPHENYLBORONIC ACID PINACOL ESTER-->2-(TRIFLUOROMETHYL)-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->(E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE-->2-Chloro-4-methoxypyrimidine-5-carbaldehyde-->4-CHLORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-METHOXY-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->3-METHOXY-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->5-FORMYL-2,4-DIMETHOXYPYRIMIDINE-->3-CYANOPYRIDIN-4-YLBORONIC ACID-->4-CYANOPYRIDIN-3-YLBORONIC ACID-->2-CYANOPYRIDIN-3-YLBORONIC ACID |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to light yellow-green liquid | [Uses]
2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors. | [Preparation]
Many routes for the synthesis of TMP have been reported. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.
|
| Spectrum Detail | Back Directory | [Spectrum Detail]
2,2,6,6-Tetramethylpiperidine(768-66-1)MS
2,2,6,6-Tetramethylpiperidine(768-66-1)1HNMR
2,2,6,6-Tetramethylpiperidine(768-66-1)13CNMR
2,2,6,6-Tetramethylpiperidine(768-66-1)IR1
2,2,6,6-Tetramethylpiperidine(768-66-1)Raman
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| Well-known Reagent Company Product Information | Back Directory | [Acros Organics]
2,2,6,6-Tetramethylpiperidine, 98%(768-66-1) | [Alfa Aesar]
2,2,6,6-Tetramethylpiperidine, 98+%(768-66-1) | [Sigma Aldrich]
768-66-1(sigmaaldrich) | [TCI AMERICA]
2,2,6,6-Tetramethylpiperidine,>98.0%(GC)(T)(768-66-1) |
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