| Identification | More | [Name]
2,2,6,6-Tetramethylpiperidine | [CAS]
768-66-1 | [Synonyms]
2,2,6,6-TETRAMETHYLPIPERIDINE
HTMP
2,2,6,6-tetramethyl-piperidin
Norpempidine
2,2,6,6-TETRAMETHYLPIPERIDINE, 99+%
2,2,6,6-Tetramethylpiperidien
TETRAMETHYLPIPERIDINE
Piperidine, 2,2,6,6-tetramethyl-
2,2,6,6-tetramethylpiperidine(TEMP)
2,2,6,6-Tetramethylpiperidine (HTMP)
2,2,6,6-Tetramethylpiperidine, 98+% | [EINECS(EC#)]
212-199-3 | [Molecular Formula]
C9H19N | [MDL Number]
MFCD00005985 | [Molecular Weight]
141.25 | [MOL File]
768-66-1.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to light yellow-green liquid | [Melting point ]
-59°C | [Boiling point ]
152 °C (lit.) | [density ]
0.837 g/mL at 25 °C(lit.)
| [vapor pressure ]
14 hPa (39 °C) | [refractive index ]
n20/D 1.445(lit.)
| [Fp ]
76 °F
| [storage temp. ]
Flammables area | [solubility ]
MISCIBLE | [form ]
Liquid | [pka]
11.07(at 25℃) | [color ]
Clear colorless to yellow | [Specific Gravity]
0.837 | [Water Solubility ]
MISCIBLE | [Sensitive ]
Air Sensitive | [Detection Methods]
GC,NMR | [BRN ]
103296 | [InChI]
1S/C9H19N/c1-8(2)6-5-7-9(3,4)10-8/h10H,5-7H2,1-4H3 | [InChIKey]
RKMGAJGJIURJSJ-UHFFFAOYSA-N | [SMILES]
CC1(C)CCCC(C)(C)N1 | [CAS DataBase Reference]
768-66-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Piperidine, 2,2,6,6-tetramethyl-(768-66-1) | [EPA Substance Registry System]
768-66-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS02,GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H226-H290-H302-H314 | [Precautionary statements ]
P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
Xn,F,C | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1992 3/PG 3
| [WGK Germany ]
2
| [RTECS ]
TN4220000
| [Autoignition Temperature]
290 °C | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29333999 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Met. Corr. 1
Skin Corr. 1A
STOT SE 3 | [Toxicity]
LD50 orally in Rabbit: 500 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Preparation Products]
2-(Trifluoromethyl)-4-isocyanatopyridine-->5-Fluoro-2-picolinic acid-->2-Chloropyridine-3,4-dicarboxylic acid-->TEMPO-->3-Bromo-2-((cyclopropylamino)methyl)benzaldehyde-->6-Chloropyridine-3,4-dicarboxylic acid-->4-(Trifluoromethyl)-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile-->2-Chloro-6-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile-->2-Bromo-6-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile-->3-Fluoro-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile-->2-(3-Methoxyphenyl)cyclohexanone-->5-(Trifluoromethyl)-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile-->2-Cyano-5-bromophenylboronic acid pinacol ester-->2-(Trifluoromethyl)-6-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile-->(E)-5-(2-Carboxyvinyl)-2,4-dimethoxypyrimidine-->2-Chloro-4-methoxypyrimidine-5-carbaldehyde-->4-Chloro-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile-->2-Methoxy-6-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile-->3-Methoxy-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile-->5-Formyl-2,4-dimethoxypyrimidine-->3-Cyanopyridin-4-ylboronic acid-->4-Cyanopyridin-3-ylboronic acid-->2-Cyanopyridin-3-ylboronic acid |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to light yellow-green liquid | [Uses]
2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors. | [Preparation]
Many routes for the synthesis of TMP have been reported. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.
|
| Spectrum Detail | Back Directory | [Spectrum Detail]
2,2,6,6-Tetramethylpiperidine(768-66-1)MS
2,2,6,6-Tetramethylpiperidine(768-66-1)1HNMR
2,2,6,6-Tetramethylpiperidine(768-66-1)13CNMR
2,2,6,6-Tetramethylpiperidine(768-66-1)IR1
2,2,6,6-Tetramethylpiperidine(768-66-1)Raman
|
| Well-known Reagent Company Product Information | Back Directory | [Acros Organics]
2,2,6,6-Tetramethylpiperidine, 98%(768-66-1) | [Alfa Aesar]
2,2,6,6-Tetramethylpiperidine, 98+%(768-66-1) | [Sigma Aldrich]
768-66-1(sigmaaldrich) | [TCI AMERICA]
2,2,6,6-Tetramethylpiperidine,>98.0%(GC)(T)(768-66-1) |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|