| Identification | Back Directory | [Name]
garcinone C | [CAS]
76996-27-5 | [Synonyms]
garcinone C
1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methylbut-2-enyl)xanthen-9-one
1,3,6,7-Tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
9H-Xanthen-9-one,1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-Methylbutyl)-2-(3-Methyl-2-buten-1-yl)- | [Molecular Formula]
C23H26O7 | [MDL Number]
MFCD11111285 | [MOL File]
76996-27-5.mol | [Molecular Weight]
414.45 |
| Chemical Properties | Back Directory | [Boiling point ]
689.0±55.0 °C(Predicted) | [density ]
1.367 | [storage temp. ]
4°C, protect from light | [solubility ]
≥ 80mg/mL in DMSO | [form ]
Solid | [pka]
7.13±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Garcinone C is isolated from the pericarps of Garcinia mangostana Linn which has multifunctional activities against Alzheimer’s disease (AD). Acetylcholinesterase inhibitor. | [Definition]
ChEBI: Garcinone C is a member of xanthones. | [in vivo]
Garcinone C (10-50 mg/kg, po, 5 days per week for 9 weeks) exhibits antitumor activity in AOM (HY-111375)/DSS (HY-116282C)-induced colon cancer mouse models[2]. | Animal Model: | AOM/DSS-induced colon cancer mouse models[2] | | Dosage: | 10-50 mg/kg | | Administration: | po, 5 days per week for 9 weeks | | Result: | Reduced the number of colon tumors. |
| [IC 50]
ATR; Stat-3; CDK7 |
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