| Identification | Back Directory | [Name]
Pipequaline | [CAS]
77472-98-1 | [Synonyms]
45319RP
PK-8165
RP-45319
Pipequaline
CAS_77472-98-1
pipequaline PK-8165
PK-8165; PK8165; PK 8165
pipequaline HCI(PK-8165)
pipequaline.HCl(for free base)
2-phenyl-4-(2-piperidin-4-ylethyl)quinoline
2-Phenyl-4-[2-(4-piperidinyl)ethyl]quinoline
Quinoline, 2-phenyl-4-[2-(4-piperidinyl)ethyl]- | [Molecular Formula]
C22H24N2 | [MDL Number]
MFCD00866983 | [MOL File]
77472-98-1.mol | [Molecular Weight]
316.44 |
| Chemical Properties | Back Directory | [Boiling point ]
489.2±30.0 °C(Predicted) | [density ]
1.078±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml | [form ]
A crystalline solid | [pka]
10.60±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay). In mice, pipequaline enhances the effects of diazepam , further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects. Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil . | [storage]
Store at -20°C |
|
|