| Identification | Back Directory | [Name]
Pipequaline | [CAS]
77472-98-1 | [Synonyms]
45319RP
PK-8165
RP-45319
Pipequaline
CAS_77472-98-1
pipequaline PK-8165
PK-8165; PK8165; PK 8165
pipequaline HCI(PK-8165)
pipequaline.HCl(for free base)
2-phenyl-4-(2-piperidin-4-ylethyl)quinoline
2-Phenyl-4-[2-(4-piperidinyl)ethyl]quinoline
Quinoline, 2-phenyl-4-[2-(4-piperidinyl)ethyl]- | [Molecular Formula]
C22H24N2 | [MDL Number]
MFCD00866983 | [MOL File]
77472-98-1.mol | [Molecular Weight]
316.44 |
| Chemical Properties | Back Directory | [Boiling point ]
489.2±30.0 °C(Predicted) | [density ]
1.078±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml | [form ]
A crystalline solid | [pka]
10.60±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay). In mice, pipequaline enhances the effects of diazepam , further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects. Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil . | [Uses]
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2]. | [in vivo]
Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3]. | [storage]
Store at -20°C | [References]
[1] Bradwejn J, et al. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-inducedactivation of hippocampal pyramidal neurons: a microiontophoretic study in the rat. Eur J Pharmacol. 1985 Jun 19;112(3):415-8. DOI:10.1016/0014-2999(85)90790-3
[2] Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42. DOI:10.1016/0028-3908(87)90096-7 |
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