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2259-96-3

2259-96-3 Structure

2259-96-3 Structure
IdentificationBack Directory
[Name]

CYCLOTHIAZIDE
[CAS]

2259-96-3
[EINECS(EC#)]

218-859-7
[Molecular Formula]

C14H16ClN3O4S2
[MDL Number]

MFCD00210192
[MOL File]

2259-96-3.mol
[Molecular Weight]

389.88
Chemical PropertiesBack Directory
[Melting point ]

234°
[density ]

1.3781 (rough estimate)
[refractive index ]

1.6100 (estimate)
[storage temp. ]

2-8°C
[pka]

pKa 9.1(30% EtOH) (Uncertain)
[form ]

White to off-white solid.
[λmax]

273nm(lit.)
[Merck ]

14,2754
[EPA Substance Registry System]

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide (2259-96-3)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

2
[RTECS ]

DK9610000
[HS Code ]

2935904000
[Toxicity]

LD50 oral in rat: > 5gm/kg
Hazard InformationBack Directory
[Uses]

Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors
[Definition]

ChEBI: 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension a d oedema.
[Brand name]

Anhydron (Lilly).
[Biological Activity]

Positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits. Also available as part of the AMPA Receptor Tocriset™ .
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