| Identification | Back Directory | [Name]
PEG5-(CH2CO2H)2 | [CAS]
77855-75-5 | [Synonyms]
PEG5-(CH2CO2H)2
CH2COOH-PEG5-CH2COOH
Bis-PEG5-acetic acid
HOOCCH2O-PEG4-CH2COOH
3,6,9,12,15-Pentaoxaheptadecanedioic acid
3,6,9,12,15-pentaoxaheptadecane-1,17-dioic acid | [Molecular Formula]
C12H22O9 | [MDL Number]
MFCD29079379 | [MOL File]
77855-75-5.mol | [Molecular Weight]
310.3 |
| Chemical Properties | Back Directory | [Boiling point ]
495.8±40.0 °C(Predicted) | [density ]
1.252±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in Water, DMSO, DMF | [form ]
Viscous Liquid | [pka]
3.09±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
PEG5-(CH2CO2H)2 is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
HOOCCH2O-PEG4-CH2COOH, compound 5, is a symmetric PEG linker, used for the synthesis of the first class of Homo-PROTAC[1]. | [References]
[1] Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830. DOI:10.1038/s41467-017-00954-1 |
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