| Identification | Back Directory | [Name]
Hydroxy-PEG1-CH2CO2tBu | [CAS]
287174-32-7 | [Synonyms]
HO-PEG1-CH2COOtBu
OH-PEG1-CH2COOtBu
Hydroxy-PEG1-CH2-Boc
Hydroxy-PEG1-CH2CO2tBu
Hydroxy-PEG1-CH2COOtBu
Hydroxy-PEG1-t-butyl acetate
tert-Butyl (2-hydroxyethoxy)acetate
tert-Butyl 2-(2-hydroxyethoxy)acetate
tert-butyl 2-(2-hydroxyethoxy)acetate(WXPC0081)
Acetic acid, 2-(2-hydroxyethoxy)-, 1,1-dimethylethyl ester | [Molecular Formula]
C8H16O4 | [MDL Number]
MFCD27635155 | [MOL File]
287174-32-7.mol | [Molecular Weight]
176.21 |
| Chemical Properties | Back Directory | [Boiling point ]
257.0±15.0 °C(Predicted) | [density ]
1.048±0.06 g/cm3(Predicted) | [form ]
liquid | [pka]
14.26±0.10(Predicted) | [color ]
Colourless | [InChI]
InChI=1S/C8H16O4/c1-8(2,3)12-7(10)6-11-5-4-9/h9H,4-6H2,1-3H3 | [InChIKey]
GIDDJWYPWOFCCS-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)COCCO |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG1-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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