| Identification | Back Directory | [Name]
PEG6-(CH2CO2H)2 | [CAS]
77855-76-6 | [Synonyms]
CAS_77855-76-6
PEG6-(CH2CO2H)2
HOOCCH2O-PEG5-CH2COOH
COOH-CH2-PEG5-CH2-COOH
3,6,9,12,15,18-hexaoxaicosanedioic acid
3,6,9,12,15,18-Hexaoxaeicosanedioic acid
3,6,9,12,15,18-Hexaoxaicosane-1,20-dioic acid | [Molecular Formula]
C14H26O10 | [MDL Number]
MFCD30458028 | [MOL File]
77855-76-6.mol | [Molecular Weight]
354.35 |
| Chemical Properties | Back Directory | [Boiling point ]
524.8±45.0 °C(Predicted) | [density ]
1.234±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water | [form ]
Oil | [pka]
3.09±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
PEG6-(CH2CO2H)2 is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation[1]. | [IC 50]
PEGs | [References]
[1] Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830. DOI:10.1038/s41467-017-00954-1 |
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