| Identification | Back Directory | [Name]
alpha-aMine-oMega-propionic acid hexaethylene glycol | [CAS]
905954-28-1 | [Synonyms]
905954-28-1
NH2-PEG6-COOH
AMINE-PEG6-COOH
Amino-PEG6-acid
Amino-PEG6-COOH
amino-dPEG 6-acid
Carboxy-PEG6-amine
NH2-PEG6-CH2CH2COOH
H2N-PEG6-CH2CH2COOH
Amino-dPEG(R)6-acid
Amino-PEG6-propionic acid
Amino-PEG6-carboxylic Acid
Amino-PEG6-acid,NH2-PEG6-COOH
α-aMine-ω-propionic acid hexaethylene glycol
21-Amino-4,7,10,13,16,19-hexaoxahenicosanoic Acid
1-Amino-3,6,9,12,15,18-hexaoxaheneicosan-21-oic acid
alpha-aMine-oMega-propionic acid hexaethylene glycol
1-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic Acid >
Propanoic acid, 3-[(17-amino-3,6,9,12,15-pentaoxaheptadec-1-yl)oxy]-
3-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid | [Molecular Formula]
C15H31NO8 | [MDL Number]
MFCD13184943 | [MOL File]
905954-28-1.mol | [Molecular Weight]
353.409 |
| Chemical Properties | Back Directory | [Boiling point ]
481.0±45.0 °C(Predicted) | [density ]
1.130±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
solid or viscous liquid | [pka]
4.28±0.10(Predicted) | [color ]
White to Almost white | [InChI]
InChI=1S/C15H31NO8/c16-2-4-20-6-8-22-10-12-24-14-13-23-11-9-21-7-5-19-3-1-15(17)18/h1-14,16H2,(H,17,18) | [InChIKey]
PVRGRRPCHFTMMD-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CCOCCOCCOCCOCCOCCOCCN |
| Hazard Information | Back Directory | [Description]
Amino-PEG6-acid is a PEG reagent composing one amine (NH2) and one terminal carboxylic acid group (CO2). The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with activated NHS esters to form a stable amide bond. | [Uses]
NH2-PEG6-CH2CH2COOH is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reagent type: cross-linking reagent
reactivity: carboxyl reactive | [IC 50]
Cleavable Linker; PEGs | [References]
[1] Jaume Pons, et al. Engineered polypeptide conjugates and methods for making thereof using transglutaminase. US20130230543A1. |
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