| Identification | More | [Name]
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol | [CAS]
779353-01-4 | [Synonyms]
PS-095760
Dinaciclib
Sch 727965
Dinaciclib (SCH 727965)
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-
(S)-3-((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyriMidin-7-ylaMino)Methyl)pyridine 1-oxide
3-[({8-ethyl-2-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrrolo[1,2-a]pyriMidin-4-yl}aMino)Methyl]pyridin-1-iuM-1-olate
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Dinaciclib (SCH727965) | [EINECS(EC#)]
214-589-6 | [Molecular Formula]
C21H28N6O2 | [MDL Number]
MFCD16037702 | [MOL File]
779353-01-4.mol | [Molecular Weight]
396.486 |
| Chemical Properties | Back Directory | [Melting point ]
>78oC (dec.) | [density ]
1.33 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
15.15±0.10(Predicted) | [color ]
White to Light Beige | [Stability:]
Hygroscopic | [InChIKey]
PIMQWRZWLQKKBJ-SFHVURJKSA-N | [SMILES]
N1(C2C=C(NCC3C=CC=[N+]([O-])C=3)N3N=CC(CC)=C3N=2)CCCC[C@H]1CCO | [CAS DataBase Reference]
779353-01-4 |
| Hazard Information | Back Directory | [Usage]
Dinaciclib is a potent and selective inhibitor of cyclin-dependent kinases which is undergoing development as oncology therapeutics. | [Uses]
Dinaciclib is a potent and selective inhibitor of cyclin-dependent kinases which is undergoing development as oncology therapeutics. | [Definition]
ChEBI: 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol is a pyrazolopyrimidine. | [Biological Activity]
dinaciclib is a potent cyclin-dependent kinase (cdk) inhibitor with ic50s for cdk2, cdk5, cdk1 and cdk9 at 1 nm, 1 nm, 3 nm, and 4 nm, respectively. [1] it is in phase i or ii | [target]
CDK2 | [storage]
Store at -20°C | [References]
[1]parry d., et al. (2010). dinaciclib (sch 727965), a novel and potent cyclin-dependent kinase inhibitor. mol cancer ther (9): 2344- 2353.
[2]martin, m. p., et al. (2013). cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. acs chemical biology 8 (11): 2360–5.
[3]payton m., et al. (2006). discovery and evaluation of dual cdk1 and cdk2 inhibitors. cancer res 66: 4299-4308. |
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