| Identification | More | [Name]
2'-Fluoro-2'-deoxyuridine | [CAS]
784-71-4 | [Synonyms]
1-(2'-FLUORO-2'-DESOXY-BETA-D-RIBOFURANOSYL)URACIL
2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-2-FLUORO-BETA-D-RIBOFURANOSYL)
2'-DEOXY-2'-FLUOROURIDINE
2'-FLUORO-2'-DEOXYURIDINE
2'-FLUORO-2'-DESOXY-URIDINE
2'-FLUORO-D-URIDINE
2'-FU
2'-FUDR
2'-DEOXY-2'-FLUOROURIDINE (2'-FLUORO-2'-DEOXYURIDINE, 2'-FU)
2'-Deoxy-2'-fluoro-D-uridine
URIDINE,2''-DEOXY-2''-FLUORO
2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''-DEOXYURIDINE)
2-FdU
2'-Fluoro-5'-O-DMT-2'-deoxyuridine | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C9H11FN2O5 | [MDL Number]
MFCD01317293 | [Molecular Weight]
246.19 | [MOL File]
784-71-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
147.0 to 153.0 °C | [density ]
1.63±0.1 g/cm3(Predicted) | [refractive index ]
53 ° (C=0.3, H2O) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Soluble in methanol. | [form ]
Powder | [pka]
9.39±0.10(Predicted) | [color ]
White to Off-white | [InChI]
InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1 | [InChIKey]
UIYWFOZZIZEEKJ-XVFCMESISA-N | [SMILES]
OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O | [CAS DataBase Reference]
784-71-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
29389090 |
| Hazard Information | Back Directory | [Description]
2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity. | [Chemical Properties]
White to almost white crystalline powder | [Uses]
A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer. | [storage]
Store at -20°C |
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