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79-81-2

79-81-2 Structure

79-81-2 Structure
IdentificationMore
[Name]

Retinol palmitate
[CAS]

79-81-2
[Synonyms]

ALL TRANS-RETINOL PALMITATE
AROVIT
RETINOL PALMITATE
RETINOL PALMITATE ALL TRANS
RETINOL PALMITATE ALL TRANS ISOMER
RETINOL PALMITATE TYPE IV: ALL TRANS
RETINYL PALMITATE
VITAMIN A PALMITATE
VITAMINE A PALMITATE
3,7-Dimethyl-9-(2,6,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol palmitate
all-trans-retinopalmitate
Ester found in fish liver oils
Optovit-A
Retinol, hexadecanoate
Retinol,hexadecanate
retinol,hexadecanoate
retinol palmitate type iv sigma grade
RETINOL PALMITATE, 100MG, NEAT
RETINOL PALMITATE TYPE VI
VITAMIN A PALMITATE 1.7 MILLION IU/G
[EINECS(EC#)]

201-228-5
[Molecular Formula]

C36H60O2
[MDL Number]

MFCD00019414
[Molecular Weight]

524.86
[MOL File]

79-81-2.mol
Chemical PropertiesBack Directory
[Melting point ]

28-29℃
[Boiling point ]

546.51°C (rough estimate)
[density ]

0.9668 (rough estimate)
[refractive index ]

1.5250 (estimate)
[Fp ]

194℃
[storage temp. ]

2-8°C
[form ]

oil
[Specific Gravity]

0.90~0.93 (20℃)
[Water Solubility ]

Soluble in chloroform, ether, and vegetable oils. Insoluble in water.
[Merck ]

13,10073
[BRN ]

1917366
[InChIKey]

VYGQUTWHTHXGQB-YFAKFODJSA-N
[Uses]

vitamin A palmitate is known as a skin “normalizer.” It acts as an antikeratinizing agent, helping the skin stay soft and plump, and improving its water-barrier properties. Because of its impact on the skin’s water-barrier properties, it is useful against dryness, heat, and pollution. It is also an anti-oxidant and is suggested for use in sunscreens. Clinical studies with vitamin A palmitate indicate a significant change in skin composition, with increases in collagen, DnA, skin thickness, and elasticity. Vitamin A palmitate’s stability is superior to retinol.
[Uses]

retinyl palmitate is a skin conditioner. This retinoid is considered a milder version of retinoic acid, given its conversion properties. once on the skin, it converts to retinol, which in turn converts to retinoic acid. Physiologically, it is credited with increasing R epidermal thickness, stimulating the production of more epidermal protein, and increasing skin elasticity. Cosmetically, retinyl palmitate is used to reduce the number and depth of fine lines and wrinkles, and prevent skin roughness resulting from uV exposure. Secondary reactions such as erythema, dryness, or irritation are not associated with retinyl palmitate. It is even more effective when used in combination with glycolic acid because it achieves greater penetration. In the united States, its maximum usage level in cosmetic formulations is 2 percent. Retinyl palmitate is the ester of retinol and palmitic acid.
[CAS DataBase Reference]

79-81-2(CAS DataBase Reference)
[NIST Chemistry Reference]

Vitamin a palmitate(79-81-2)
[EPA Substance Registry System]

79-81-2(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

T,Xn
[Risk Statements ]

R63:Possible risk of harm to the unborn child.
[Safety Statements ]

S53:Avoid exposure-obtain special instruction before use .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
[RIDADR ]

UN1170 - class 3 - PG 2 - Ethanol, solution
[WGK Germany ]

3
[RTECS ]

VH6860000
[F ]

8-10-23
[TSCA ]

Yes
[HS Code ]

29362100
[Safety Profile]

Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
[Toxicity]

LD50 (10 day) in mice, rats (mg/kg): 6060, 7910 orally (Kamm)
Hazard InformationBack Directory
[Chemical Properties]

95.0-100.5% Absorbance @325 nm ≥0.85%
[Purification Methods]

The palmitate is separated from retinol by column chromatography on water-deactivated alumina with hexane containing a very small percentage of acetone. It is also chromatographed on TLC silica gel G, using pet ether/isopropyl ether/acetic acid/water (180:20:2:5) or pet ether/acetonitrile/acetic acid/water (190:10:1:15) to develop the chromatogram. It is then recrystallised from propylene at low temperature (below -47o). [Beilstein 6 IV 4135.]
Spectrum DetailBack Directory
[Spectrum Detail]

Retinol palmitate (79-81-2) IR1
Retinol palmitate (79-81-2) MS
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

79-81-2(sigmaaldrich)
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