| Chemical Properties | Back Directory | [Boiling point ]
600.5±65.0 °C(Predicted) | [density ]
1.427±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Soluble: =10 mg/ml | [form ]
Solid | [pka]
3.27±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
ASP2905 hydrochloride is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3). | [Uses]
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities[1][2]. | [in vivo]
ASP2905 treatment inhibits hyperlocomotion induced by Phencyclidine. And significantly ameliorates Phencyclidine-induced prolongation of immobility time in mice subjected to the forced swimming test[2]. | Animal Model: | Male ddY mice (aged 4-5 weeks) injected with Phencyclidine hydrochloride (PCP)[2] | | Dosage: | 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg | | Administration: | Oral administration; once | | Result: | Inhibited hyperlocomotion induced by Phencyclidine. |
| [References]
[1] Shinji Takahashi, et al. Neurochemical and neuropharmacological characterization of ASP2905, a novel potent selective inhibitor of the potassium channel KCNH3. Eur J Pharmacol. 2017 Sep 5;810:26-35. DOI:10.1016/j.ejphar.2017.05.045
[2] Shinji Takahashi, et al. ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice. Behav Brain Res. 2020 Jan 27;378:112315. DOI:10.1016/j.bbr.2019.112315 |
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