| Identification | Back Directory | [Name]
AG-L-5968 | [CAS]
793035-88-8 | [Synonyms]
CS-280
AG-L-5968
AG-L-59687
AG-L 59687;AG-L59687
α-D-Glucopyranoside, 8-[2-amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purin-9-yl]octyl
8-[2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purin-9-yl]octyl-alpha-D-glucopyranoside | [Molecular Formula]
C24H34BrN5O7S | [MDL Number]
MFCD28101024 | [MOL File]
793035-88-8.mol | [Molecular Weight]
616.53 |
| Hazard Information | Back Directory | [Uses]
O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, O6BTG-C8-αGlu can completely inhibit MGMT in HeLaS3 cells. Even when applied chronically at high doses (up to 20 μM), it does not exhibit cytotoxicity. O6BTG-C8-αGlu is suitable for research on MGMT-related cancer diseases[1]. | [References]
[1] Kaina B, et al. Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with nonconjugated inhibitors and effect on fotemustine and temozolomide-induced cell death. J Pharmacol Exp Ther. 2004 Nov;311(2):585-93. DOI:10.1124/jpet.104.071316 |
|
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|