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81228-35-5

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81228-35-5 Structure

81228-35-5 Structure
IdentificationBack Directory
[Name]

1-[4-[2-[2-(4-fluorophenyl)ethoxy]ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol
[CAS]

81228-35-5
[Synonyms]

1-[4-[2-[2-(4-fluorophenyl)ethoxy]ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol
2-Propanol, 1-[4-[2-[2-(4-fluorophenyl)ethoxy]ethoxy]phenoxy]-3-[(1-methylethyl)amino]-
[Molecular Formula]

C22H30FNO4
[MOL File]

81228-35-5.mol
[Molecular Weight]

391.48
Chemical PropertiesBack Directory
[Boiling point ]

526.2±50.0 °C(Predicted)
[density ]

1.125±0.06 g/cm3(Predicted)
[pka]

13.92±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

Ro 31-1118 Free base is a compound exhibiting weak antihypertensive activity in patients with mild hypertension. Ro 31-1118 Free base demonstrated a reduction in heart rates and blood pressure post-exercise at varying doses. Ro 31-1118 Free base exhibited linear pharmacokinetics within the 10-80 mg dose range. Ro 31-1118 Free base showed no significant impact on diastolic blood pressure or adverse effects during the study.
[References]

[1] Ro 31-1118, a new cardioselective beta-adrenoceptor antagonist. Pharmacokinetics and effects on heart rate and blood pressure in mild hypertensives DOI:10.1007/BF00613451
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