| Identification | Back Directory | [Name]
(SAR1,ILE4,8)-ANGIOTENSIN II | [CAS]
185461-45-4 | [Synonyms]
(SAR1,ILE4,8)-ANGIOTENSIN II
SAR-ARG-VAL-ILE-ILE-HIS-PRO-ILE
SAR-ARG-VAL-ILE-ILE-HIS-PRO-ILE-OH
REF DUPL: Sar-Arg-Val-Ile-Ile-His-Pro-Ile-OH
(Sar 1,Ile4·8)-Angiotensin II trifluoroacetate salt Sar-Arg-Val-Ile-Ile-His-Pro-Ile-OH trifluoroacetate salt | [Molecular Formula]
C43H75N13O9 | [MDL Number]
MFCD08458670 | [MOL File]
185461-45-4.mol | [Molecular Weight]
918.14 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.72±0.22(Predicted) | [color ]
White to off-white | [Sequence]
{Sar}-Arg-Val-Ile-Ile-His-Pro-Ile |
| Hazard Information | Back Directory | [Uses]
(Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β[1]. | [IC 50]
Angiotensin II Type 1 | [References]
[1] Sanni SJ, et al. [Sar1, Ile4, Ile8]-angiotensin II Potentiates Insulin Receptor Signalling and Glycogen Synthesis in Hepatocytes. Basic Clin Pharmacol Toxicol. 2018 May;122(5):460-469. DOI:10.1111/bcpt.12937 |
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