| Identification | More | [Name]
Zolpidem | [CAS]
82626-48-0 | [Synonyms]
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE HEMITARTRATE
N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]PYRIMIDINE-3-ACETAMIDE
SL-80.0750
ZOLPIDEM
2-a)pyridine-3-acetamide,2-(4-methylphenyl)-n,n,6-trimethyl-imidazo(
N,N,6-Trimethyl-2-p-tolylimidazo[1,2-a]pyridine-3-acetamide
N,N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
ZOLPIDEM >96% IMIDAZOPYRIDINE DERIV
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyrimidine-3-acetamide, SL-80.0750
6-methyl-N,N-dimethyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine-3-yl]-acetamide (intermediate of zolpidem)
N,N-dimethyl-2-[3-methyl-8-(4-methylphenyl)-1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl]acetamide
6-METHYL-N,N-DIMETHYL-2-(4-METHYL-PHENYL)-IMIDAZO[1,2-A]PYRIDINE-3-YL]-ACETAMIDE
2-(4-Methylphenyl)-6-Methylimidazo(1,2,a)Pyridine
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-
Ivadal
N，N，6-Trimethyl-2-(4-methylphenyl)imidazo[1，2-α]pyridine-3-acetamide
Niotal
SL-80．0750-23N
Stilnoct：Stilnox | [Molecular Formula]
C19H21N3O | [MDL Number]
MFCD00153885 | [Molecular Weight]
307.39 | [MOL File]
82626-48-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
189-191°C | [density ]
1.12±0.1 g/cm3(Predicted) | [Fp ]
9℃ | [storage temp. ]
Store at RT | [solubility ]
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
| [form ]
solid
| [pka]
6.2(at 25℃) | [color ]
white
| [Water Solubility ]
<10mg/L(room temperature) | [Usage]
A selective benzodiazepine receptor agonist not related chemically to benzodiazepines | [CAS DataBase Reference]
82626-48-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Zolpidem(82626-48-0) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
3
| [RTECS ]
NJ5109750
| [HS Code ]
2933996500 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Methylamine-->Oxalyl chloride-->Acetamide, 2-diazo-N,N-dimethyl--->6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-->2-Bromo-N,N-dimethylacetamide-->2-PropynaMide, N,N-diMethyl--->6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid-->Benzenebutanamide, β-bromo-N,N,4-trimethyl-γ-oxo--->Dimethylamine-->Dimethylamine hydrochloride-->2-Amino-5-methylpyridine | [Preparation Products]
6-METHYL-N,N-DIMETHYL-2-(4-METHYLPHENYL)-2-HYDROXYIMIDAZO[1,2-ALPHA]PYRIDINE-3-ACETAMIDE |
| Hazard Information | Back Directory | [Description]
Zolpidem (Item No. 15792) is an analytical reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused.1,2,3 This product is intended for research and forensic applications. | [Description]
Zolpidem (Item No. 20648) is a certified reference material that is functionally categorized as a sedative. It is a non-benzodiazepine drug that is used in the treatment of insomnia, and it has been recreationally abused.1,2,3 This product is intended for research and forensic applications. | [Description]
Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at
type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep
disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the
side-effects and abuse potential of classical benzodiazepines. It is currently being studied
as a pre-operative sedative. | [Chemical Properties]
Off-White Solid | [Originator]
Synthelabo (France) | [Uses]
A selective benzodiazepine receptor agonist not related chemically to benzodiazepines | [Uses]
A selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic.
Controlled substance (depresssant). | [Definition]
ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position. | [Brand name]
Ambien (Sanofi Aventis);Stilnox. | [General Description]
Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001. |
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