| Identification | More | [Name]
p-Trifluoromethoxy phenol | [CAS]
828-27-3 | [Synonyms]
4-HYDROXYPHENYL TRIFLUOROMETHYL ETHER
4-HYDROXYTRIFLUOROMETHOXYBENZENE
4-(TRIFLUOROMETHOXY)PHENOL
P-(TRIFLUOROMETHOXY)PHENOL
TIMTEC-BB SBB006554
p-Trifluoromethoxy Phenol 4-Trifluoromethoxy Phenol
4-(Trifluoromethoxy)phenol 98%
4-(Trifluoromethoxy)phenol98%
p-(Triflourmethoxy)phenol
PHENOL,4-(TRIFLUOROMETHOXY)
TFMOPO | [EINECS(EC#)]
212-583-0 | [Molecular Formula]
C7H5F3O2 | [MDL Number]
MFCD00040988 | [Molecular Weight]
178.11 | [MOL File]
828-27-3.mol |
| Chemical Properties | Back Directory | [Appearance]
clear brown liquid | [Melting point ]
17-18°C | [Boiling point ]
92 °C25 mm Hg(lit.)
| [density ]
1.375 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.447(lit.)
| [Fp ]
187 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform, Methanol | [form ]
Liquid | [pka]
9.30±0.13(Predicted) | [color ]
Clear brown | [Specific Gravity]
1.375 | [Usage]
Intermediates of Liquid Crystals | [BRN ]
1945934 | [InChIKey]
NWVVVBRKAWDGAB-UHFFFAOYSA-N | [CAS DataBase Reference]
828-27-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Phenol, 4-(trifluoromethoxy)-(828-27-3) |
| Questions And Answer | Back Directory | [Uses]
4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors. |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H314-H412 | [Precautionary statements ]
P270-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2927 | [WGK Germany ]
2
| [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29095090 |
| Hazard Information | Back Directory | [Chemical Properties]
clear brown liquid | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 25, p. 1097, 1982 DOI: 10.1021/jm00351a018 | [Synthesis]
General procedure for the synthesis of 4-trifluoromethoxyphenol from 4-trifluoromethoxyphenylboronic acid: In an atypical method, a flask containing 4-trifluoromethoxyphenylboronic acid (100 mg, 0.82 mmol) was taken to which 10 mol% of iron(III) oxide photocatalyst (13.1 mg) and tetrahydrofuran (2 ml) were added. The reaction mixture was stirred in a normal open flask under diffuse sunlight until complete consumption of the feedstock was shown by thin layer chromatography (TLC) detection. Upon completion of the reaction, the reaction was quenched with water and filtered to remove the catalyst. The filtrate was concentrated under vacuum. The crude product was purified by column chromatography on silica gel (100-200 mesh) with an eluent of 15:1 ethyl acetate/hexane, resulting in 73.2 mg (95% yield) of pure crystalline 4-trifluoromethoxyphenol. | [References]
[1] Tetrahedron Letters, 2014, vol. 55, # 4, p. 811 - 814
[2] Tetrahedron Letters, 2015, vol. 55, # 4, p. 811 - 814
[3] Synthesis (Germany), 2014, vol. 46, # 3, p. 295 - 300 |
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