| Identification | Back Directory | [Name]
ANTI-EAPII (TTRAP) | [CAS]
828934-41-4 | [Synonyms]
CS-119
ANTI-EAPII
(+)-Etomoxir
Etomoxir(Nasalt)
Etomoxir hydrate sodium
(R)-(+)-Etomoxir Sodium
(+)-Etomoxir sodium salt
(+)-etomoxir sodium hydrate
(R)-(+)-EtoMoxir (sodiuM salt)
(+)-Etomoxir sodium salt hydrate
(+)-Etomoxir hydrate sodium salt
(R)-((addition))-Etomoxir sodium salt
InSolution Etomoxir - CAS 828934-41-4 - Calbiochem
sodium (R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate
sodium (S)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate
(R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate sodium...
(2R)-2-[6-(4-Chlorophenoxy)hexyl]oxiranecarboxylic acid sodium salt
(R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
r(+)-2-[6-(4-chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt hydrate
R(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid hydrate sodium salt
(R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate sodiuM salt
or (R)-EtoMoxir, sodiuM salt | [Molecular Formula]
C15H18ClO4NaH2O | [MDL Number]
MFCD11044452 | [MOL File]
828934-41-4.mol | [Molecular Weight]
322.76 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: freely soluble | [form ]
White solid | [color ]
white | [Water Solubility ]
H2O: freely soluble | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | [InChI]
InChI=1/C15H19ClO4.Na.H/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;/t15-;;/s3 | [InChIKey]
WENJLJJSJDAJDN-QCUBGVIVSA-M | [SMILES]
C([C@]1(OC1)C(=O)O)CCCCCOC1C=CC(Cl)=CC=1.[NaH] |&1:1,r| |
| Questions And Answer | Back Directory | [Description]
(R)-(+)-Etomoxir sodium salt(828934-41-4) is R-form of Etomoxir sodium salt. Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1).
| [Background]
(R)-(+)-Etomoxir sodium salt(828934-41-4) is an irreversible inhibitor of carnitine palmitoyltransferase 1(CPT-1).
Etomoxir (100 μM) has no effect on T cells cultured in high glucose. In contrast, there is a significant increase in apoptosis in etomoxir-treated cultures stimulated with antigen under low glucose conditions.
C57BL/6 mice treated with Etomoxir (15 mg/kg, i.p) reduce the infiltration of immune cells in the central nervous system. Only a small number of macrophages, activated microglia or T cells are present, while reducing the inflammatory response and Demyelinating reaction.
| [Application]
(R)-(+)-Etomoxir sodium salt(828934-41-4) is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.
| [In Vitro]
(R)-(+)-Etomoxir sodium salt is R-form of Etomoxir sodium salt. Etomoxir binds irreversibly to the catalytic site of CPT-1 inhibiting its activity, but also upregulates fatty acid oxidation enzymes. Etomoxir is developed as an inhibitor of the mitochondrial carnitine palmitoyltransferase-1 (CPT-1) located on the outer mitochondrial membrane. Etomoxir, in the liver can act as peroxisomal proliferator, increasing DNA synthesis and liver growth. Thus, etomoxir, in addition of being a CPT1 inhibitor could be considered as a PPARalpha agonist. Etomoxir is a member of the oxirane carboxylic acid carnitine palmitoyl transferase I inhibitors and has been suggested as a therapeutic agent for the treatment of heart failure. Acute Etomoxir treatment irreversibly inhibits the activity of carnitine palmitoyltransferase I. As a result, fatty acid import into the mitochondria and β-oxidation is reduced, whereas cytosolic fatty acid accumulates and glucose oxidation is elevated. Prolonged incubation (24 h) with Etomoxir produces diverse effects on the expression of several metabolic enzyme. | [In Vivo]
(R)-(+)-Etomoxir sodium salt(828934-41-4) is R-form of Etomoxir sodium salt. Etomoxir is an inhibitor of free fatty acid (FFA) oxidation-related key enzyme CPT1. P53 interacts directly with Bax, which is inhibited by Etomoxir, further confirming the direct interaction of P53 and Bax, and the involvement of FAO-mediated mitochondrial ROS generation in db/db mice. Rats are injected daily with Etomoxir, a specific CPT-I inhibitor, for 8 days at 20 mg/kg of body mass. Etomoxir-treated rats display a 44% reduced cardiac CPT-I activity. The treatment of Lewis rats for 8 days with 20 mg/kg Etomoxir does not alter blood glucose, which is in line with comparable etomoxir-feeding studies. Similarly, Etomoxir feeding does not affect general growth characteristics such as gain in body mass, nor does it affect hindlimb muscle mass. However, heart mass and liver mass are both significantly increased by 11% in Etomoxir-treated rats.
| [References]
1. Rupp H, et al. The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz. 2002 Nov;27(7):621-36
2. Xu FY, et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 2003 Feb;44(2):415-23
3. Li J, et al. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Sci Rep. 2015 Jul 31;5:12724
4. Luiken JJ, et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. Biochem J. 2009 Apr 15;419(2):447-55.
5. Rupp H, Zarain-Herzberg A, Maisch B. The Use of Partial Fatty Acid Oxidation Inhibitors for Metabolic Therapy of Angina Pectoris and Heart Failure. Herz, 2002, 27(7): 621-636.
6. Shriver L P, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Scientific Reports, 2011, 1.
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| Hazard Information | Back Directory | [Uses]
(+)-Etomoxir sodium salt hydrate(828934-41-4) has been used as an inhibitor of carnitine palmitoyltransferase 1 (CPT-1) in breast tumor cell lines and mice tumor. It has also been used as an inhibitor of fatty acid oxidation in human primary prostate epithelial cells and lymphocytes.
| [Preparation]
Mix raw material A with solvent (tetrahydrofuran), then add catalyst, heat to a certain temperature, add p-chlorophenol, nitrogen, stirring reaction, the reaction solution is dry, remove the solvent, the resulting solid is re-dispersed in anhydrous ethanol, add sodium hydroxide solution, stirring to 30-50 ° C reaction, after the reaction is concentrated under reduced pressure, concentrate is dried, the product is produced. | [General Description]
(+)-Etomoxir sodium salt hydrate(828934-41-4) belongs to oxirane carboxylic acid group of compounds and mediates metabolic channeling of fatty acid precursors. It favors oxidative stress in T cells and prevents T cell differentiation. It inhibits fatty acid oxidation and promotes hunger and food intake. Etomoxir impairs myeloid-derived suppressor cells mediated tumor and could have potential therapeutic potential.
| [Biochem/physiol Actions]
Irreversible O-carnitine palmitoyltransferase-1 (CPT-1) inhibitor; PPARα activator | [storage]
Store at -20°C |
|
| Company Name: |
SynAsst Chemical.
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| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
D&C Chemicals
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| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
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