| Identification | Back Directory | [Name]
(-)-3,4-Dihydroxynorephedrine | [CAS]
829-74-3 | [Synonyms]
BA 2818
Nordefri
l-Cobefrin
CORBADRINE
Neo-cobefrin
Isoadrenaline
LEVONORDEFRIN
D-(-)-Cobefrin
Levonordefrin Base
Dioxynorepinephrine
Levonordefrin (200 mg)
L-α-Methylnoradrenaline
Corbadrine, Levonordefrin,
(-)-α-methylnorepinephrine
(-)3,4-DIHYDROXYNOREPHEDRINE
Dihydroxyphenylpropanolamine
(-)-3,4-Dihydroxynorephedrine
(-)-3,4-DIHYDROXYNOREPHREDRINE
3,4-Dihydrophenyl-1-amino-2-propanol-1
4-(2-amino-1-hydroxy-propyl)pyrocatechol
Corbadrine, Levonordefrin, l-Norephedrine
(-)-3,4-DIHYDROXYNOREPHEDRINE, TECH., 90 %
(-)-3,4-DIHYDROXYNOREPHEDRINE*APPROX. 90 %
4-(2-Amino-1-hydroxypropyl)benzene-1,2-diol
4-[2-AMINO-1-HYDROXYPROPYL]-1,2-BENZENEDIOL
1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)-
(1R,2S)-2-Amino-1-(3,4-dihydroxyphenyl)-1-propanol
1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)- (9CI)
BENZYL ALCOHOL, alpha-(1-AMINOETHYL)-3,4-DIHYDROXY-
(-)-4-[(1R,2S)-2-Amino-1-hydroxypropyl]-1,2-benzenediol
α-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol, (-)-α-Methylnorepinephrine, 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, L-4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol
α-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol, (-)-α-Methylnorepinephrine, 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, L-4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, Levonordefrin | [Molecular Formula]
C9H13NO3 | [MDL Number]
MFCD00134415 | [MOL File]
829-74-3.mol | [Molecular Weight]
183.2 |
| Chemical Properties | Back Directory | [Appearance]
White Powder | [Melting point ]
212-215°C dec. | [alpha ]
D25 -31.0° (c = 0.5 in 0.01N HCl) | [Boiling point ]
431.6±40.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
9.59±0.10(Predicted) | [color ]
white to light brown | [Merck ]
13,6725 | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1 | [InChIKey]
GEFQWZLICWMTKF-CDUCUWFYSA-N | [SMILES]
C[C@H](N)[C@H](O)c1ccc(O)c(O)c1 |
| Hazard Information | Back Directory | [Chemical Properties]
White Powder | [Uses]
A vasoconstrictor which also increases the potency and duration of anesthesia produced by local anesthetics | [Uses]
Vasoconstrictor;Adrenergic receptor agonist | [Definition]
ChEBI: Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It has a role as an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant. | [Brand name]
Neo-Cobefrin (Cook-Waite). |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
20/21/22-36/37/38 | [Safety Statements ]
26-36 | [RIDADR ]
UN 2811 6.1 / PGII | [WGK Germany ]
3
| [HS Code ]
2922504500 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | [Toxicity]
LD50 in mice (mg/kg): 12.6 i.v. (Luduena) |
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