| Identification | More | [Name]
3-Amino-1,2-propanediol | [CAS]
616-30-8 | [Synonyms]
1,2-DIHYDROXY-1-PROPYLAMINE
1,2-DIHYDROXY-3-AMINOPROPANE
1-AMINO-2,3-PROPANDIOL
1-AMINO-2,3-PROPANEDIOL
1-AMINOGLYCEROL
2,3-DIHYDROXY-1-PROPYLAMINE
3-AMINO-1,2-DIHYDROXYPROPANE
3-AMINO-1,2-PROPANDIOL
(+/-)-3-AMINO-1,2-PROPANEDIOL
3-AMINO-1,2-PROPANEDIOL
3-AMINOPROPANE-1,2-DIOL
APD
1,2-Propanediol, 3-amino-
1-aminopropanediol
2,3-Dihydroxypropylamine
2,3-Propandiol-1-amine
3-amino-2-propanediol
(+/-)-3-AMINO-1,2-PROPANEEDIOL
3-AMINO-1,2-PROOPANEDIOL
3-Aminopropane-1,2-diol 99% | [EINECS(EC#)]
210-475-8 | [Molecular Formula]
C3H9NO2 | [MDL Number]
MFCD00008140 | [Molecular Weight]
91.11 | [MOL File]
616-30-8.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to pale yellow viscous liquid | [Melting point ]
55-57 °C | [Boiling point ]
264-265 °C739 mm Hg(lit.)
| [density ]
1.175 g/mL at 25 °C(lit.)
| [vapor pressure ]
<1 hPa (20 °C) | [refractive index ]
n20/D 1.492(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
>1000g/l soluble | [form ]
liquid (highly viscous)
| [pka]
12.11±0.35(Predicted) | [color ]
Clear colorless to pale yellow | [Specific Gravity]
1.175 | [PH]
11 (100g/l, H2O, 20℃) | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [BRN ]
1719121 | [InChIKey]
KQIGMPWTAHJUMN-UHFFFAOYSA-N | [LogP]
-2.079 (est) | [CAS DataBase Reference]
616-30-8(CAS DataBase Reference) | [NIST Chemistry Reference]
3-Amino-1,2-propanediol(616-30-8) | [EPA Substance Registry System]
616-30-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2735 8/PG 2
| [WGK Germany ]
2
| [RTECS ]
TY2800000
| [F ]
10-21 | [Hazard Note ]
Corrosive | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29221980 | [Toxicity]
LD50 orally in Rabbit: 7500 mg/kg |
| Hazard Information | Back Directory | [Description]
APD is a calcium metabolism regulator useful in the treatment of Paget's disease,
tumor-induced hypercalcemia and other bone disorders involving increased osteoclastic
activity. | [Chemical Properties]
clear colorless to pale yellow viscous liquid | [Originator]
Henkel (W. Germany) | [Application]
(±)-3-Amino-1,2-propanediol is used as a reactant in the synthesis of lipid-like delivery molecules(lipidoids) for RNA interference (RNAi) therapeutics. It is also used in the synthesis of the bioactive template to prepare cationic α-helical polypeptides and various cationic polymers for gene delivery. | [Uses]
3-Amino-1,2-propanediol is used in the preparation of iohexol, which is a X-CT non-ionic contrast medium. It acts as a starting material in the production of specialty materials. | [Preparation]
3-Amino-1,2-propanediol is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with ammonia in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps. | [Brand name]
Aminomux | [Safety Profile]
Poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of NOx. | [storage]
3-Amino-1,2-propanediol absorbs moisture and needs to be kept in a container sealed. Store in cool, dry conditions in well-sealed containers. |
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