| Identification | More | [Name]
Naphazoline | [CAS]
835-31-4 | [Synonyms]
2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE
2-[1-NAPHTHYLMETHYL]IMIDAZOLINE HYDROCHLORIDE
2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM CHLORIDE
4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE
NAPHAZOLINE HCL
NAPHAZOLINE HYDROCHLORIDE
1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-
2-(1-Naphethylmethyl)-2-imidazoline
2-(1-naphthylmethyl)-2-imidazolin
2-(1-Naphthylmethyl)-2-imidazoline
2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole
2-(alpha-Naphthylmethyl)-imidazoline
2-(Naphthyl-(1')-methyl)imidazolin
2-(naphthyl-(1’)-methyl)imidazolin
2-Imidazoline, 2-(1-naphthylmethyl)-
4,5-dihydro-2-(1-naphthalenylmethyl)-1h-imidazol
alpha-Naphthylmethyl imidazoline
alpha-naphthylmethylimidazoline
Antan
CIBA 2020/r | [EINECS(EC#)]
212-641-5 | [Molecular Formula]
C14H15ClN2 | [MDL Number]
MFCD00012554 | [Molecular Weight]
246.74 | [MOL File]
835-31-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R25:Toxic if swallowed. | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
NJ4375000
|
| Hazard Information | Back Directory | [Originator]
Privine,Ciba,US,1942 | [Uses]
Adrenergic (vasoconstrictor). | [Uses]
Naphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe
and chronic inflammatory conditions, in particular for inflammation of the antrum of
Highmore as well as for stopping nosebleeds. | [Definition]
ChEBI: 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes. | [Manufacturing Process]
2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula
(produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12
parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and
simultaneously stirring until ammonia escapes no longer. The alcohol is then
distilled and the residue mixed with 40 parts of benzene and 1.8 parts of
caustic potash. Stirring is continued for some time whereby the imidazoline
base is dissolved in benzene. The benzene residue is recrystallized several
times from toluene. | [Brand name]
Albalon (Allergan); Nafazair
(Bausch & Lomb); Nafazair (Pharmafair); Naphcon
(Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis). | [Therapeutic Function]
Nasal decongestant | [Synthesis]
Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized
from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline
derivative (11.1.36) upon reaction with ethylendiamine [40].
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