| Identification | More | [Name]
Naphazoline nitrate | [CAS]
5144-52-5 | [Synonyms]
2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE NITRATE
2-(1-NAPHTHYLMETHYL)IMIDAZOLINE NITRATE
2-[1-NAPHTHYLMETHYL]IMIDAZOLINE NITRATE SALT
2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM NITRATE
LABOTEST-BB LT00134653
NAPHAZOLINE NITRATE
NAPHAZOLINE NITRATE SALT
NAPHAZOLINI NITRAS
2-(1-naphthylmethyl)-2-imidazolinmononitrate
4,5-dihydro-2-(1-naphthalenylmethyl)-1h-imidazolmononitrate
naftizin
naphthisen
naphthizen
naphtyzin
privinenitrate
rinazin
naphazoline nitrate crystalline
NAPHAZOLINE NITRATE, PH EUR
NAPHAZOLINE NITRATE EXTRA PURE PH EUR
1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, mononitrate | [EINECS(EC#)]
225-915-4 | [Molecular Formula]
C14H15N3O3 | [MDL Number]
MFCD00014316 | [Molecular Weight]
273.29 | [MOL File]
5144-52-5.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder. | [Melting point ]
167-170 °C
| [storage temp. ]
2-8°C | [solubility ]
Sparingly soluble in water, soluble in ethanol (96 per cent). | [form ]
neat | [color ]
White to off-white | [Sensitive ]
Hygroscopic | [BRN ]
3779329 | [Major Application]
pharmaceutical (small molecule) | [InChI]
InChI=1S/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4) | [InChIKey]
ZAHXYMFVNNUHCP-UHFFFAOYSA-N | [SMILES]
C12C(C=CC=C1)=CC=CC=2CC1=NCCN1.[N+]([O-])(=O)O | [CAS DataBase Reference]
5144-52-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P301+P312+P330 | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
3249 | [WGK Germany ]
3
| [RTECS ]
NJ4376000
| [F ]
3-10 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29332900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder. | [Uses]
antihistamine | [Definition]
ChEBI: Naphazoline nitrate is a member of naphthalenes. | [Indications]
Naphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion.
Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma.
Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977). | [in vivo]
Naphazoline nitrate (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1]. | Animal Model: | Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1] | | Dosage: | 0.2 mg/mL, 10 μl per eye | | Administration: | Intraperitoneal injection (IP), once | | Result: | Significantly suppressed conjunctival dye leakage in mice with histamine or antigen?induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice. |
| [IC 50]
IL-1β; IL-6; IL-4 |
|
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 18918157536; |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Maya High Purity Chemicals
|
| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
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