| Identification | More | [Name]
Minoxidil sulphate | [CAS]
83701-22-8 | [Synonyms]
6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE-3-OXIDE SULFATE
MINOXIDIL SULFATE
MINOXIDIL SULPHATE
U-58838
minoxidilsulfateester
MINOXIDIL SUFATE ETHYLATED
1,6-Dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-2-pyrimidinamine
Minoxidil O-sulfate | [EINECS(EC#)]
635-997-7 | [Molecular Formula]
C9H15N5O4S | [MDL Number]
MFCD06248907 | [Molecular Weight]
289.31 | [MOL File]
83701-22-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
175-180°C | [density ]
1.75±0.1 g/cm3(Predicted) | [RTECS ]
UV6260494 | [storage temp. ]
−20°C
| [solubility ]
Acetone (Slightly), DMSO (Slightly) | [form ]
White solid. | [pka]
-4.99±0.18(Predicted) | [color ]
White to Off-White | [Usage]
A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant | [Stability:]
Light Sensitive - Protect from Light, Store in Freezer | [InChI]
InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17) | [InChIKey]
AGMYAAIWWVATKU-UHFFFAOYSA-N | [SMILES]
C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1 | [CAS DataBase Reference]
83701-22-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T+ | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust . | [WGK Germany ]
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| Questions And Answer | Back Directory | [Application]
Minoxidil sulfate was the drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp. The water solubility characteristics of minoxidil sulfate increases the absorption.
Before that, minoxidil sulfate had been used as vasodilator drug prescribed as an oral tablet to treat high blood pressure and it’s can used for refractory hypertension and renal hypertension. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability.
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| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant | [Uses]
specifically opens ATP-sensitive K channels, strong vascular smooth muscle relaxer, active minoxidil metabolite | [Biological Functions]
Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener. | [Biochem/physiol Actions]
Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness. | [in vitro]
Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS. |
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