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837424-39-2

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837424-39-2 Structure

837424-39-2 Structure
IdentificationBack Directory
[Name]

YM 2447690
[CAS]

837424-39-2
[Synonyms]

YM 244769
YM 2447690
N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
[Molecular Formula]

C27H24ClFN2O3
[MOL File]

837424-39-2.mol
[Molecular Weight]

478.942
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at RT
[solubility ]

Soluble to 100 mM in DMSO
[form ]

Powder
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

YM 2447690 is a sodium-calcium exchanger (NCX) inhibitor used for the prevention and treatment of reperfusion arrhythmias, myocardial contracture and necrosis.
[Uses]

YM 2447690 is a sodium-calcium exchanger (NCX) inhibitor used for the prevention and treatment of reperfusion arrhythmias, myocardial contracture and necrosis. This compound has neuroprotective properties.
[in vivo]

YM-244769 (0.1-1 mg/kg; p.o.; once) exhibits dose-dependently natriuretic action in mice and significantly increased urinary excretion of Ca2+ as well as Ca2+/Cr ratio[2].

Animal Model:Wild-type C57BL/6J mice and NCX-KO mice[2]
Dosage:0.1, 0.3 and 1 mg/kg
Administration:Oral administration, once
Result:Caused a dose-dependent increase (up to approximately 200%) in urine volume and urinary excretion of electrolytes (Na+, K+ and Cl-). Natriuretic actions were equivalently observed in NCX1-KO and WT, but disappeared in NCX2-KO and double KO.
[storage]

Desiccate at RT
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