| Identification | Back Directory | [Name]
CP 94253 hydrochloride | [CAS]
845861-39-4 | [Synonyms]
1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride
CP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor | [Molecular Formula]
C15H20ClN3O | [MOL File]
845861-39-4.mol | [Molecular Weight]
293.8 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at RT | [solubility ]
Soluble to 25 mM in water and to 100 mM in DMSO | [form ]
Powder | [color ]
Pale yellow | [InChI]
InChI=1S/C15H19N3O.ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11;/h3-5,10,16-17H,2,6-9H2,1H3;1H | [InChIKey]
PIIOXKQIZCVXMD-UHFFFAOYSA-N | [SMILES]
O(C1=CC=C2NC=C(C3=CCNCC3)C2=N1)CCC.Cl |
| Hazard Information | Back Directory | [Description]
CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay). It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats. | [Uses]
CP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity. | [storage]
Desiccate at RT | [References]
[1] DR. B. KENNETH KOE. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253[J]. Drug Development Research, 1992, 26 3: 241-250. DOI: 10.1002/ddr.430260305
[2] E W FISH K A M S Faccidomo. Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253.[J]. Psychopharmacology, 1999, 146 4: 391-399. DOI: 10.1007/pl00005484
[3] EWA TATARCZY?SKA. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: A possible mechanism of action[J]. European journal of pharmacology, 2005, 516 1: Pages 46-50. DOI: 10.1016/j.ejphar.2005.04.025
[4] EWA CHOJNACKA-WóJCIK Ewa T Aleksandra K?odzińska. The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action[J]. Journal of Pharmacy and Pharmacology, 2010, 57 2: 253-257. DOI: 10.1211/0022357055399 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|