| Identification | More | [Name]
1-Naphthalenesulfonyl chloride | [CAS]
85-46-1 | [Synonyms]
1-NAPHTHALENESULFONYL CHLORIDE
1-NAPHTHALENESULPHONYL CHLORIDE
NAPHTHALENE-1-SULFONYL CHLORIDE
NAPHTHALENE-1-SULPHONYL CHLORIDE
NAPHTHOSULFOCHLORIDE
.alpha.-Napthalenesulfonylchloride
1-Naphthylsulfonyl chloride
alpha-Naphthalenesulfochloride
alpha-Naphthalenesulfonyl chloride
Naphthalene sulfonyl chloride
1-NAPTHALENESULFONIC CHLORIDE
1-Chlorosulfonylnaphthalene
1-Naphthalenesulfonic acid chloride
Naphthalene-1-sulfonic acid chloride | [EINECS(EC#)]
201-609-6 | [Molecular Formula]
C10H7ClO2S | [MDL Number]
MFCD00003984 | [Molecular Weight]
226.68 | [MOL File]
85-46-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to beige crystalline powder | [Melting point ]
64-67 °C (lit.) | [Boiling point ]
194-195 °C/13 mmHg (lit.) | [density ]
1.3661 (estimate) | [Fp ]
194-195°C/13mm | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
chloroform: soluble25mg/mL, clear to very slightly hazy, colorless to yellow | [form ]
powder to crystal | [color ]
White to Almost white | [Water Solubility ]
insoluble | [Sensitive ]
Moisture Sensitive | [BRN ]
2099333 | [InChI]
1S/C10H7ClO2S/c11-14(12,13)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H | [InChIKey]
DASJFYAPNPUBGG-UHFFFAOYSA-N | [SMILES]
ClS(=O)(=O)c1cccc2ccccc12 | [CAS DataBase Reference]
85-46-1(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Naphthalenesulfonyl chlorine(85-46-1) | [EPA Substance Registry System]
85-46-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [F ]
10-21 | [Hazard Note ]
Corrosive | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29049090 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Eye Dam. 1
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
white to beige crystalline powder | [Uses]
1-Naphthalenesulfonyl chloride has been used in the preparation of 5?-O-naphthaleneiulfonyldeoxyuridine and 1-sulfonylindazole derivatives. The derivatives of this compound is used for quantitative metabolome analysis New set of isotope reagents, 12C4-, 12C213C2-, and 13C4-5-diethylamino-naphthalene-1-sulfonyl chloride (DensCl), in combination with liquid chromatography Fourier-transform ion cyclotron resonance mass spectrometry (LC-FTICR-MS) is used for improved analysis of the amine- and phenol-containing submetabolome. | [General Description]
1-Naphthalenesulfonyl chloride undergoes desulfitative carbonylative Stille cross-coupling reaction with tinglucal derivative. | [Purification Methods]
If the IR indicates the presence of OH, then treat it with an equal weight of PCl5 and heat it at ca 100o for 2hours, cool and pour onto ice + H2O, stir well and filter off the solid. Wash the solid with cold H2O and dry the solid in a vacuum desiccator over P2O5 + solid KOH. Extract the solid with pet ether (b 40-60o), filter off any insoluble solid and cool. Collect the crystalline sulfonyl chloride and recrystallise it from dry Et2O, pet ether or *C6H6/pet ether. If large quantities are available, then it can be distilled under high vacuum. [Fierz-Davaid & Weissenbach Helv Chim Acta 3 2312 1920.] The sulfonamide crystallises from EtOH (m 150.5o) or H2O (m 153o). [Beilstein 11 H 175, 11 II 93, 11 IV 383.] |
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