| Identification | Back Directory | [Name]
Coenzyme A | [CAS]
85-61-0 | [Synonyms]
COA
COA-SH
Coalip
Lucina
Aluzime
Thiol-CoA
COENZYME A
CONENZYME A
Coenzyme ASH
D-Coenzyme A
COENZYME A (COA)
COENZYME A HYDRATE
COENZYM A FREE ACID
Coenzyme A/Q0/Q10
Coenzyme a, free acid
Coenzyme A hydrate,CoA
CoenzyMe A hydrate (free acid)
COENZYME A FREE ACID FROM YEAST
Coenzyme A, free acid, hydrate (COA)
Coenzyme A,75%,free acid, lyophilized
Coenzyme A, free acid, lyophilized, 75%
Coenzyme A, free acid, lyophilized, min. 75% (enzym.)
Adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) P'-[(R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester
[5-(6-Aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid | [EINECS(EC#)]
201-619-0 | [Molecular Formula]
C21H36N7O16P3S | [MDL Number]
MFCD06795839 | [MOL File]
85-61-0.mol | [Molecular Weight]
767.54 |
| Chemical Properties | Back Directory | [Appearance]
yellowish lyophilisate | [density ]
1.96±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [pka]
9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+) | [Merck ]
13,2491 | [BRN ]
77809 | [LogP]
-4.358 (est) | [EPA Substance Registry System]
Coenzyme A(85-61-0) |
| Hazard Information | Back Directory | [Chemical Properties]
yellowish lyophilisate | [Description]
Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism.1 About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a 5-step process that requires ATP.2 The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.3 | [Uses]
A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms. | [Definition]
ChEBI: Tetraanion of coenzyme A. | [General Description]
Coenzyme A is structurally composed of 2-aminoethanethiol, pantothenic acid and phosphorylated adenosine phosphate. | [Biochem/physiol Actions]
Coenzyme A is a cofactor involved in acyl group transfer. It is essential for carbohydrate, lipid and protein metabolism. Coenzyme A acts as a cofactor for vitamin B coenzymes. | [Purification Methods]
The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.] |
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