| Identification | Back Directory | [Name]
3-Azidopropanoic acid NHS ester | [CAS]
850180-76-6 | [Synonyms]
N3-C2-NHS ester
3-Azidopropanoic acid NHS ester
(2,5-Dioxopyrrolidin-1-yl) 3-azidopropanoate
3-azidopropanoate-N-hydroxysuccinimide ester | [Molecular Formula]
C7H8N4O4 | [MDL Number]
MFCD24452814 | [MOL File]
850180-76-6.mol | [Molecular Weight]
212.17 |
| Hazard Information | Back Directory | [Description]
3-Azidopropanoic acid NHS ester is an azidopropanoic acid linker that contains an NHS ester group. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkyne, DBCO and BCN. The NHS ester can react with other primary amines to label proteins and antibodies. | [Uses]
N3-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Non-cleavable Linker | [References]
[1] Gregson SJ, et al. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507. DOI:10.1021/acs.jmedchem.7b00736 |
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