| Identification | Back Directory | [Name]
2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]- | [CAS]
866363-70-4 | [Synonyms]
N3-C5-NHS ester
2,5-dioxopyrrolidin-1-yl 6-azidohexanoate
1-[(6-Azidohexanoyl)oxy]pyrrolidine-2,5-dione
2,5-Pyrrolidinedione, 1-[(6-azido-1-oxohexyl)oxy]-
6-azidohexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester | [Molecular Formula]
C10H14N4O4 | [MDL Number]
MFCD25968077 | [MOL File]
866363-70-4.mol | [Molecular Weight]
254.243 |
| Hazard Information | Back Directory | [Description]
Azido-Aca-NHS has an azide and NHS ester end group. The azide can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The NHS ester can react with amine groups to form stable amide bonds. | [Uses]
N3-C5-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C5-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Non-cleavable Linker | [References]
[1] Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507. DOI:10.1021/acs.jmedchem.7b00736 |
|
|