| Identification | More | [Name]
3-Chloro-2-fluorobenzaldehyde | [CAS]
85070-48-0 | [Synonyms]
3-CHLORO-2-FLUOROBENZALDEHYDE
TIMTEC-BB SBB003987
3-Chloro-2-fluorobenzaldehyde 97%
3-Chloro-2-fluorobenzaldehyde97% | [Molecular Formula]
C7H4ClFO | [MDL Number]
MFCD01631571 | [Molecular Weight]
158.56 | [MOL File]
85070-48-0.mol |
| Chemical Properties | Back Directory | [Appearance]
lightyellowliqui | [Boiling point ]
214 °C (lit.) | [density ]
1.35 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.545(lit.)
| [Fp ]
186 °F
| [storage temp. ]
Refrigerator | [form ]
clear liquid | [color ]
Light orange to Yellow to Green | [Sensitive ]
Air Sensitive | [BRN ]
5861249 | [InChI]
InChI=1S/C7H4ClFO/c8-6-3-1-2-5(4-10)7(6)9/h1-4H | [InChIKey]
YAOZCMANASAVFN-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC=CC(Cl)=C1F | [CAS DataBase Reference]
85070-48-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29130000 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
lightyellowliqui | [Uses]
3-Chloro-2-fluorobenzaldehyde is an intermediate used to synthesize small-molecule inhibitors of MDM2-p53 interaction as antitumor agents. It is also used to prepare flavonoid derivatives as selective neuromedin U 2 receptor agonists for obesity treatment. | [Application]
3-Chloro-2-fluorobenzaldehyde is an important fine chemical intermediate used in organic and pharmaceutical synthesis.
| [General Description]
3-Chloro-2-fluorobenzaldehyde is a fluorinated benzaldehyde derivative. | [Hazard]
3-Chloro-2-fluorobenzaldehyde causes skin irritation and serious eye irritation.
| [Synthesis]
36.3 g of sodium bicarbonate and 500 g of dichloromethane were added to a 1 L four-necked flask, followed by 0.5 g of TOMO as a catalyst. The reaction mixture was cooled to 0 to 5°C with stirring. To this cooled mixture was slowly added a mixed solution of 50 g of (3-chloro-2-fluorophenyl)methanol and 100 g of dichloromethane. Next, 230 g of sodium hypochlorite solution was added slowly and dropwise. The reaction mixture was held at 0 to 5°C for 1 hour. The progress of the reaction was monitored by sampling and the reaction was stopped when the content of raw (3-chloro-2-fluorophenyl)methanol was ≤ 1%. After completion of the reaction, the mixture was left to stratify. The organic layer (dichloromethane layer) was separated and the dichloromethane was recovered by simple distillation. Finally, vacuum distillation of the remaining oil layer gave 46.1 g of 3-chloro-2-fluorobenzaldehyde with 97.5% product purity and 91% yield. | [References]
[1] Patent: CN104529729, 2016, B. Location in patent: Paragraph 0087; 0088 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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