| Identification | Back Directory | [Name]
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate | [CAS]
85547-56-4 | [Synonyms]
85547-56-4
PIPERAQUINE PHOSPHATE
antimalarial drugs PIPERAQUINE PHOSPHATE
2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)
4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C29H32Cl2N6.H3PO4 | [MDL Number]
MFCD08457544 | [MOL File]
85547-56-4.mol | [Molecular Weight]
633.51 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Insoluble; | [form ]
Solid | [color ]
Off-white to light yellow | [Water Solubility ]
Water: 2 mg/mL (3.16 mM) | [InChIKey]
KATNPMSTHHZOTK-UHFFFAOYSA-N | [SMILES]
C(N1CCN(C2=C3C(=NC=C2)C=C(Cl)C=C3)CC1)CCN1CCN(C2=C3C(=NC=C2)C=C(Cl)C=C3)CC1.P(O)(O)(O)=O |
| Hazard Information | Back Directory | [Uses]
Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2]. | [in vivo]
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg?h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg?h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1]. | Animal Model: | Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1] | | Dosage: | 0, 10, 30, 90 mg/kg | | Administration: | A single i.p. administration | | Result: | The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
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| Animal Model: | Male Swiss mice (6 weeks old)[1] | | Dosage: | 90 mg/kg (Pharmacokinetic Analysis) | | Administration: | A single i.p. administration | | Result: | t1/2=17.8 d; AUC=33.5 mg?h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |
| [storage]
Store at -20°C | [References]
[1] Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. DOI:10.1128/AAC.00878-07
[2] Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87. DOI:10.2165/00003495-200565010-00004 |
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