| Identification | More | [Name]
Creatine phosphate | [CAS]
67-07-2 | [Synonyms]
CREATINE PHOSPHATE
n-phosphocreatine
n-(phosphonoamidino)-sarcosine
n-[imino(phosphonoamino)methyl]-n-methyl-glycin
N-(N1-(dihydroxyphosphinyl)amidino)sarcosine
phosphocreatine
PhosphoCreatineSodiumC4H8N3Na2O5P
Creatine phosphoric acid
2-[methyl-(N'-phosphonocarbamimidoyl)amino]acetic acid
phosphagen
Neoton
N-Phosphorocreatine | [EINECS(EC#)]
200-643-9 | [Molecular Formula]
C4H10N3O5P | [MDL Number]
MFCD00152044 | [Molecular Weight]
211.11 | [MOL File]
67-07-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
>175oC (dec.) | [Boiling point ]
449.1±47.0 °C(Predicted) | [density ]
1.83±0.1 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Water | [form ]
Solid | [pka]
pKa 4.7± 0.01(H2O,t =25)(Approximate) | [color ]
White to Off-White | [Stability:]
Hygroscopic | [CAS DataBase Reference]
67-07-2(CAS DataBase Reference) | [EPA Substance Registry System]
67-07-2(EPA Substance) |
| Hazard Information | Back Directory | [Uses]
Phosphocreatine used in the synthesis of hydroxypatite nanorod/nanosheets. Phosphocreatine is used in the treatment of heart and brain ischemia. | [Definition]
ChEBI: N-phosphocreatine is a phosphoamino acid consisting of creatine having a phospho group attached at the primary nitrogen of the guanidino group. It has a role as a human metabolite and a mouse metabolite. It is a phosphoamino acid and a phosphagen. It is functionally related to a creatine. It is a conjugate acid of a N-phosphocreatinate(2-). | [Enzyme inhibitor]
This phosphagen (FW = 211.11 g/mol; CAS 67-07-2; 922-32-7 for disodium salt), known almost as commonly as creatine phosphate, is the primary cytosolic phosphoryl donor for the resynthesis of MgATP from MgADP through the action of creatine kinase in vertebrates and some invertebrates. While abundant in skeletal and cardiac muscle (40-60 mM), nonmuscle cells contain 3-5 mM, and some fungi (e.g., Candida) have intermediate levels of this metabolite. Note: The reported inhibitory action by creatine kinase is often due to impurities (e.g., the inhibition of 5’- nucleotidase is due to an impurity in the commercial phosphocreatine). The reported inhibition of AMP deaminase is due mainly to the presence of pyrophosphate. Phosphocreatine is a hygroscopic solid and very soluble in water. Unstable in acid, all is hydrolyzed after one minute at 100°C in 1.0 M HCl, and half is hydrolyzed in 4 min at 25°C in 0.5 M HCl. Molybdate and certain buffers reportedly accelerate hydrolysis. Hydrolysis is slow under slightly alkaline conditions (e.g., pH 7.8). Nevertheless, solutions should always be freshly prepared and stored frozen. Target(s): adenylate cyclase; AMP deaminase; glutamine synthetase; H+-extrusion by plasma membrane ATPase; NADH peroxidase; phosphofructokinase; and thiamin-phosphate diphosphorylase. | [storage]
Store at -20°C |
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