| Identification | Back Directory | [Name]
K-252C | [CAS]
85753-43-1 | [Synonyms]
K-252C
Staurosporinone
Staurosporonine
STAUROSPORINE AGLYCONE
Staurosporinone, K-252c
K-252c(Staurosporinone)
K252c, Ready Made Solution
Staurosporine Aglycone >99%
K-252c - CAS 85753-43-1 - Calbiochem
Staurosporinone, Staurosporine Aglycone
6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, 6,7,12,13-tetrahydro-
K252c / Staurosporine Aglycone>99%/ Staurosporinone, K-252C /
6,7,12,13-Tetrahydro-5H-Indolo[2,3-A]Pyrrolo[3,4-C]Carbazol-5-One | [Molecular Formula]
C20H13N3O | [MDL Number]
MFCD00236435 | [MOL File]
85753-43-1.mol | [Molecular Weight]
311.34 |
| Chemical Properties | Back Directory | [Melting point ]
>200°C (dec.) | [storage temp. ]
−20°C
| [solubility ]
DMSO: 10 mg/mL, soluble
| [form ]
solid
| [color ]
Pale Brown to Light Brown | [Water Solubility ]
Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water. |
| Hazard Information | Back Directory | [Uses]
Inhibits protein kinase C | [Biological Activity]
Inhibitor of protein kinase C (IC 50 = 2.45 μ M) that displays ~ 10-fold selectivity over protein kinase A (IC 50 = 25.7 μ M). Also inhibits β -lactamase, malate dehydrogenase and chymotrypsin (IC 50 values are 8, 8 and 10 μ M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC 50 values range from 0.13-0.32 μ M). Shows no activity against herpes simplex virus (HSV). | [storage]
Store at -20°C | [References]
1. fabre s, prudhomme m, rapp m. protein kinase c inhibitors; structure-activity relationships in k252c-related compounds. bioorg med chem 1993,1:193-196.2. hashimoto s. k-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in pc12h cells. j cell biol 1988,107:1531-1539.3. raychaudhuri sp, sanyal m, weltman h, kundu-raychaudhuri s. k252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. j invest dermatol 2004,122:812-819. |
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