| Identification | Back Directory | [Name]
23-HYDROXYBETULINIC ACID | [CAS]
85999-40-2 | [Synonyms]
ANEMOSAPOGININ
23-HYDROXYBETULINIC ACID
23-Hydroxybetulinic Acid, ≥98%
23-hydroxy butulinic acid (23-HBA)
23-HYDROXYBETULINIC ACID USP/EP/BP
23-Hydroxybetulinic acid 85999-40-2
Anemosapogenin,23-Hydroxybetulinic acid
3β,23-Dihydroxylup-20(29)-en-28-oic acid
23-Hydroxybetulinic acid (Anemosapogenin)
3beta,23-Dihydroxylup-20(29)-en-28-oic acid
Lup-20(29)-en-28-oic acid, 3,23-dihydroxy-, (3β,4α)-
(1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13aR,13bR)-9-Hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic Acid
(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS,13bR)-9-hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid | [Molecular Formula]
C30H48O4 | [MDL Number]
MFCD00238612 | [MOL File]
85999-40-2.mol | [Molecular Weight]
472.7 |
| Chemical Properties | Back Directory | [Melting point ]
>293°C (dec.) | [Boiling point ]
585.8±25.0 °C(Predicted) | [density ]
1.106 | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
Methanol (Slightly, Heated), Pyridine (Slightly) | [form ]
Solid | [pka]
4.60±0.70(Predicted) | [color ]
White | [InChIKey]
HXWLKAXCQLXHML-WGOZWDAUSA-N | [SMILES]
C([C@]12CC[C@H]([C@]1([H])[C@@]1([H])CC[C@]3([H])[C@]4(CC[C@@H]([C@@]([C@]4([H])CC[C@]3([C@@]1(CC2)C)C)(C)CO)O)C)C(=C)C)(=O)O |
| Hazard Information | Back Directory | [Description]
23-hydroxy Betulinic acid is a triterpenoid that has been found in P. chinensis and has anticancer activity.1 It inhibits proliferation of K562, B16, and HeLa cells (IC50s = 39.9, 78.5, and 80 μM, respectively), as well as human umbilical vein endothelial cells (HUVECs; IC50 = 94.8 μM). It halts the cell cycle at the S phase and induces apoptosis in K562 cells in a concentration-dependent manner with a loss of the mitochondrial membrane potential and an increase in Bax and cytochrome C protein levels. | [Uses]
23-Hydroxybetulinic Acid is a potential cytoxic agent in the treatment of cancer. Apoptotic effect. Antiproliferative. | [Definition]
ChEBI: 23-Hydroxybetulinic acid is a triterpenoid. It has a role as a metabolite. It derives from a hydride of a lupane. | [References]
[1] MING LIU. Cytotoxicity of the compounds isolated from Pulsatilla chinensis saponins and apoptosis induced by 23-hydroxybetulinic acid.[J]. Pharmaceutical Biology, 2015, 53 1: 1-9. DOI: 10.3109/13880209.2014.907323 |
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