| Identification | Back Directory | [Name]
FPTQ | [CAS]
864863-72-9 | [Synonyms]
FPTQ
6-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline
Quinoline, 6-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]- | [Molecular Formula]
C17H12FN5 | [MOL File]
864863-72-9.mol | [Molecular Weight]
305.31 |
| Hazard Information | Back Directory | [Uses]
FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively[1]. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo[2]. | [in vivo]
FPTQ (5-20 μM) decreases the number of neutrophils migrating to the amputation site in zebrafish larvae by tail amputation. In the tailfin wound method, the number of neutrophils collecting at the wound site also decreases in a dose-dependent manner in zebrafish[2].In a LPS-induced inflammation zebrafish model, LPS solution is injected into the yolks of Tg(mpx:EGFP)i114 zebrafish larvae and exposed the zebrafish larvae immediately to FPTQ treatment.FPTQ (20 μM; 4 hours) significantly decreases the fluorescent neutrophils after yolk injection and has an anti-inflammatory effect during the early phase of inflammation[2]. | [IC 50]
Human mGluR1: 6 nM (IC50); Mouse mGluR1: 1.4 nM (IC50) | [References]
[1] Fujinaga M et al. Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem, 2011 Jan 1, 19(1):102-10. DOI:10.1016/j.bmc.2010.11.048
[2] Geum Ran Kim, et al. Anti-inflammatory effect of a novel synthetic compound 1-((4-fluorophenyl)thio)isoquinoline in RAW264.7 macrophages and a zebrafish model. Fish Shellfish Immunol. 2019 Apr;87:395-400. DOI:10.1016/j.fsi.2019.01.030 |
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