| Identification | Back Directory | [Name]
CB-52 | [CAS]
869376-90-9 | [Synonyms]
11-(2-HEXYL-5-HYDROXYPHENOXY)UNDECANOIC ACID CYCLOPROPYLAMIDE | [Molecular Formula]
C26H43NO3 | [MDL Number]
MFCD09951899 | [MOL File]
869376-90-9.mol | [Molecular Weight]
417.62 |
| Chemical Properties | Back Directory | [Melting point ]
57.3 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) | [Boiling point ]
595.9±30.0 °C(Predicted) | [density ]
1.03±0.1 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol: PBS (pH 7.2)(1:2): 0.3 mg//ml | [form ]
A crystalline solid | [pka]
9.86±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
CB-52 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 210 and 30 nM, respectively.1 In vitro, CB-52 behaves primarily as a CB1 receptor partial agonist and a CB2 receptor neutral antagonist.2 | [Uses]
CB-52 is the ligand and neutral antagonist of CB2 cannabinoid receptor[1]. | [in vivo]
CB-52 (1 and 5 mg/kg, i.p.) decreases pain threshold to thermal stimulation in rats, and blocks WIN55,212-2 (2.5 mg/kg, i.p.) caused anti-nociceptive effect[1].
| [References]
1. Brizzi, A., Brizzi, V., Cascio, M.G., et al. Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors J. Med. Chem. 48,7343-7350(2005).
2. Cascio, M.G., Bisogno, T., Palazzo, E., et al. In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands Br. J. Pharmacol. 149,431-440(2006). |
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